INT350588

Context Info Confidence 0.38 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.05 Pain Relevance 0

chromosome (Mlh1) ATPase activity (Mlh1) nucleus (Mlh1) cell cycle (Mlh1)

Anatomy Link Frequency MLH1 3 Mlh1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 54 5.00 cytokine 9 5.00 Inflammatory response 9 5.00 Bioavailability 6 5.00 abdominal pain 3 5.00 addiction 3 5.00 Crohn's disease 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Microsatellite Instability 42 99.48 Cancer 189 98.72 Chromosomal Instability 3 89.04 Genomic Instability 21 87.00 Lung Cancer 27 77.28 Toxicity 33 63.28 Death 12 51.52 Intestinal Cancer 108 49.76 Hyperplasia 51 15.32 Stress 63 13.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MSI is often a result of the loss or hindrance of DNA mismatch repair (MMR) genes such as MutL homolog 1 (MLH1).

Negative_regulation (loss) of MLH1 in MLH1 associated with microsatellite instability

1) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.12 Pain Relevance 0

Immunoprecipitation of methylated H3K9 following Cr(VI) exposure was shown to coprecipitate the MLH1 promoter; moreover, the treatment of cells with Cr(VI) produced time- and dose-dependent decreases in messenger RNA (mRNA) levels of MLH1 (Sun et al., 2009).

Negative_regulation (decreases) of MLH1 in MLH1

2) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.80 Pain Relevance 0

MSI is often a result of the loss or hindrance of DNA mismatch repair (MMR) genes such as MutL homolog 1 (MLH1).

Negative_regulation (loss) of MutL homolog 1 in MLH1 associated with microsatellite instability

3) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.12 Pain Relevance 0

General Comments

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