INT350824

Context Info Confidence 0.22 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.85 Pain Relevance 0

small molecule metabolic process (INS) endoplasmic reticulum (SELS) enzyme binding (SELS) carbohydrate metabolic process (INS) cytoplasm (SELS) cell-cell signaling (INS)

Anatomy Link Frequency adipocytes 2 INS (Homo sapiens) SELS (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 5.00 cytokine 4 5.00 Angina 4 5.00 Inflammatory marker 3 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Obesity 71 99.24 Disorder Of Lipid Metabolism 12 91.00 Diabetes Mellitus 21 88.24 Hepatocellular Cancer 2 59.36 INFLAMMATION 8 5.00 Insulin Resistance 6 5.00 Cardiovascular Disease 5 5.00 Coronary Artery Disease 5 5.00 Cv General 3 Under Development 4 5.00 Metabolic Disorder 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have also shown that SELS gene expression is stimulated by insulin in isolated human adipocytes.

insulin Positive_regulation (stimulated) of Gene_expression (expression) of SELS in adipocytes associated with obesity

1) Confidence 0.22 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.85 Pain Relevance 0

General Comments

This test has worked.