INT35086

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 40
Total Number 43
Disease Relevance 22.55
Pain Relevance 18.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 18
macrophage 4
spleen 4
colon 2
bladder 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 196 100.00 Very High Very High Very High
Morphine 64 100.00 Very High Very High Very High
cINOD 11 99.96 Very High Very High Very High
Arthritis 258 99.92 Very High Very High Very High
rheumatoid arthritis 162 99.88 Very High Very High Very High
qutenza 10 99.82 Very High Very High Very High
Paracetamol 9 99.62 Very High Very High Very High
fluoxetine 21 99.58 Very High Very High Very High
Pain 17 98.58 Very High Very High Very High
Neuritis 11 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 89 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Arthritis 207 99.92 Very High Very High Very High
Rheumatoid Arthritis 162 99.88 Very High Very High Very High
Immunization 6 99.80 Very High Very High Very High
Parkinson's Disease 2 99.10 Very High Very High Very High
Htlv Types I And Ii 2 99.00 Very High Very High Very High
Disease 126 98.98 Very High Very High Very High
Colitis 11 98.64 Very High Very High Very High
Pain 13 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IFN-gamma mRNA expression increased significantly in the bladder, but not in the lung of the EAC mice.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of IFN-gamma mRNA in bladder
1) Confidence 0.69 Published 2008 Journal BJU Int. Section Body Doc Link 18710451 Disease Relevance 0.20 Pain Relevance 0
This effect depends on the presence of CD4(+) T cells and requires IFN-gamma production and MLC phosphorylation.


Positive_regulation (depends) of Gene_expression (production) of IFN-gamma in T cells
2) Confidence 0.64 Published 2003 Journal Gastroenterology Section Body Doc Link 12949725 Disease Relevance 0 Pain Relevance 0
RESULTS: Repeated stress induced an overexpression of colonic IFN-gamma.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IFN-gamma
3) Confidence 0.64 Published 2003 Journal Gastroenterology Section Body Doc Link 12949725 Disease Relevance 0.07 Pain Relevance 0
The activated state of these cells was supported by the enhanced production of interferon-gamma in the presence of IND in vitro culture of the peritoneal exudate cells.
Positive_regulation (enhanced) of Gene_expression (production) of interferon-gamma
4) Confidence 0.54 Published 2001 Journal FEMS Immunol. Med. Microbiol. Section Abstract Doc Link 11476975 Disease Relevance 0.42 Pain Relevance 0.43
Pancreatic expression of gamma-interferon (IFN-gamma) initiates a cascade of pathogenic changes that include pancreatic inflammation, islet cell destruction, hyperglycemia, and islet regeneration.
Positive_regulation (Pancreatic) of Gene_expression (expression) of IFN-gamma associated with hyperglycemia and inflammation
5) Confidence 0.50 Published 1995 Journal Diabetes Section Abstract Doc Link 7556951 Disease Relevance 0.39 Pain Relevance 0.05
Pancreatic expression of gamma-interferon (IFN-gamma) initiates a cascade of pathogenic changes that include pancreatic inflammation, islet cell destruction, hyperglycemia, and islet regeneration.
Positive_regulation (Pancreatic) of Gene_expression (expression) of gamma-interferon associated with hyperglycemia and inflammation
6) Confidence 0.50 Published 1995 Journal Diabetes Section Abstract Doc Link 7556951 Disease Relevance 0.34 Pain Relevance 0.05
Also the production of IL-6 and IFN-gamma was increased by these peptides.
Positive_regulation (increased) of Gene_expression (production) of IFN-gamma
7) Confidence 0.50 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.60
The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.
Positive_regulation (enhanced) of Gene_expression (levels) of interferon-gamma in macrophage associated with necrosis, cancer and morphine
8) Confidence 0.49 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.61 Pain Relevance 0.76
The treatment with a single dose of inactivated Candida blastospores induced interleukin-2(IL-2), interferon-gamma (IFNgamma) and interleukin-4 (IL-4) production at 24 h after in vitro restimulation of splenocytes.
Positive_regulation (induced) of Gene_expression (production) of interferon-gamma
9) Confidence 0.49 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.33 Pain Relevance 0.57
However, more severe clinical and histopathological manifestations, a stronger T cell response to P0 peptide 180-199, and enhanced IFN-gamma production in the spleen were observed in the EAN of CD4(-)8(-) and microMT mice, but these were not obviously different from those of wild-type mice.
Positive_regulation (enhanced) of Gene_expression (production) of IFN-gamma in T cell associated with neuritis
10) Confidence 0.49 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12429233 Disease Relevance 0.89 Pain Relevance 0.78
The treatment with a single dose of inactivated Candida blastospores induced interleukin-2(IL-2), interferon-gamma (IFNgamma) and interleukin-4 (IL-4) production at 24 h after in vitro restimulation of splenocytes.
Positive_regulation (induced) of Gene_expression (production) of IFNgamma
11) Confidence 0.49 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.33 Pain Relevance 0.57
Mitogen-stimulated splenocytes had a lower production of interferon-gamma as well as an increase in the secretion of tumor necrosis factor-alpha.
Positive_regulation (increase) of Gene_expression (production) of interferon-gamma associated with necrosis and cancer
12) Confidence 0.49 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 1.22 Pain Relevance 0.70
The presence of the opioid peptides alpha- and beta-endorphin (-End) but not methionine enkephalin (Met-enk) in in vitro cultures of purified CD4+ T cells, stimulated with concanavalin A in the presence of irradiated spleen cells, resulted in a threefold stimulation of IL-2, IL-4, and IFN-gamma production.
Positive_regulation (stimulation) of Gene_expression (production) of IFN-gamma in spleen associated with enkephalin and opioid
13) Confidence 0.49 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.44
Fluoxetine administration also increased mitogen-induced T-cell proliferation and Tumor Necrosis Factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) expression, without altering CD4(+)/CD8(+) ratio.
Positive_regulation (increased) of Gene_expression (expression) of IFN-gamma in T-cell associated with necrosis, cancer and fluoxetine
14) Confidence 0.47 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18342838 Disease Relevance 0.97 Pain Relevance 0.91
Fluoxetine administration also increased mitogen-induced T-cell proliferation and Tumor Necrosis Factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) expression, without altering CD4(+)/CD8(+) ratio.
Positive_regulation (increased) of Gene_expression (expression) of Interferon-gamma in T-cell associated with necrosis, cancer and fluoxetine
15) Confidence 0.47 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18342838 Disease Relevance 0.97 Pain Relevance 0.91
However, only when NFATc1 was co-overexpressed with c-fos was the inhibitory effect of morphine on IFN-gamma promoter counteracted.
Positive_regulation (co-overexpressed) of Gene_expression (co-overexpressed) of IFN-gamma associated with morphine
16) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.33 Pain Relevance 1.23
Regarding effects on cytokines, no significant changes were detected in the amount of Interferon-gamma (IFNgamma) and Interlukin-10 (IL-10) produced by lymphocytes obtained from the spleens of any of the shocked mice.
Neg (no) Positive_regulation (changes) of Gene_expression (produced) of IFNgamma in lymphocytes associated with cytokine
17) Confidence 0.44 Published 2007 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 18075858 Disease Relevance 0.41 Pain Relevance 0.25
In contrast to the suppressive effects of hydrocortisone, none of the 16-epiestriol concentrations inhibited concanavalin A-stimulated IFN-gamma production by spleen cells, as determined by ELISA.
Positive_regulation (stimulated) of Gene_expression (production) of IFN-gamma in spleen
18) Confidence 0.44 Published 1998 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 9858313 Disease Relevance 0.28 Pain Relevance 0.21
This effect depends on the presence of CD4(+) T cells and requires IFN-gamma production and MLC phosphorylation.


Positive_regulation (requires) of Gene_expression (production) of IFN-gamma in T cells
19) Confidence 0.43 Published 2003 Journal Gastroenterology Section Body Doc Link 12949725 Disease Relevance 0 Pain Relevance 0
RESULTS: Repeated stress induced an overexpression of colonic IFN-gamma.
Positive_regulation (induced) of Gene_expression (overexpression) of IFN-gamma
20) Confidence 0.43 Published 2003 Journal Gastroenterology Section Body Doc Link 12949725 Disease Relevance 0.07 Pain Relevance 0

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