INT3512

Context Info Confidence 0.60 First Reported 1976 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 7.71 Pain Relevance 1.13

Anatomy Link Frequency B cells 2 gut 1 Igha (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 4 96.80 fibrosis 73 91.20 Pain 7 83.28 Arthritis 11 80.00 Inflammatory marker 1 79.00 abdominal pain 7 78.64 Angina 2 76.88 withdrawal 1 74.56 agonist 22 70.68 Dopamine 2 70.32

Disease Link Frequency Relevance Heat Thrombosis 4 99.92 Congenital Anomalies 3 99.92 Disease 54 99.12 Hypersensitivity 5 99.00 Immunodeficiency 1 98.96 Occupational Lung Diseases 2 98.52 Infection 16 97.80 Purpura 4 96.50 Systemic Lupus Erythematosus 4 96.48 Vasculitis 2 94.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IgA secretory piece and HBs antigen were not found in the glomeruli and early complement components C1q and C4 were absent.

Neg (not) Gene_expression (found) of IgA

1) Confidence 0.60 Published 1976 Journal Clin. Nephrol. Section Abstract Doc Link 780026 Disease Relevance 1.15 Pain Relevance 0.07

Levels of serum IgG, IgA, and IgM fell significantly during treatment with SP, but none of the other changes reached statistical significance.

Gene_expression (Levels) of IgA

2) Confidence 0.08 Published 1996 Journal Arthritis Rheum. Section Body Doc Link 8702450 Disease Relevance 0.08 Pain Relevance 0

The pathogenic mechanisms underlying HSP are poorly understood, and whilst they may include gut infection, other mucosal mechanisms such as drugs or hypersensitivity have been postulated to lead to abnormalities in IgA synthesis [12].

Gene_expression (synthesis) of IgA in gut associated with purpura, congenital anomalies, hypersensitivity and infection

3) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2045102 Disease Relevance 2.77 Pain Relevance 0.30

IgM was not significantly changed after glucocorticoid treatment in the patients with AIP, while IgG, IgG4 and IgA decreased.

Gene_expression (decreased) of IgA

4) Confidence 0.06 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19626266 Disease Relevance 0.12 Pain Relevance 0

Patients exposed to asbestos, and particularly those with asbestosis, have an increased incidence of ANA and other autoantibodies, and raised levels of IgG and IgA.

Gene_expression (levels) of IgA associated with occupational lung diseases

5) Confidence 0.06 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.18 Pain Relevance 0.56

IgA ACAs were present in high titers in all groups and had little discriminant value in predicting thrombotic risk.

Gene_expression (present) of IgA

6) Confidence 0.06 Published 1998 Journal Thromb. Res. Section Abstract Doc Link 9622037 Disease Relevance 0.80 Pain Relevance 0.08

METHODS: We examined the immune condition of AIP patients before and after glucocorticoid treatment, focusing on serum levels of IgG, IgG4, IgM and IgA, and compared the results with those in other hepato-pancreatic diseases, such as autoimmune hepatitis, primary biliary cirrhosis, chronic pancreatitis and pancreatic carcinoma.

Gene_expression (levels) of IgA

7) Confidence 0.06 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19626266 Disease Relevance 0.19 Pain Relevance 0

For phenotypic confirmation, mice were left unimmunized and verification of transferred IgMa -expressing B cells within the splenic FO B cell compartment of C57BL/6-Ighb recipient mice 1 d after transfer was validated by flow cytometry.

Gene_expression (expressing) of IgMa in B cells

8) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.09 Pain Relevance 0

For phenotypic confirmation, mice were left unimmunized and verification of transferred IgMa -expressing B cells within the splenic FO B cell compartment of C57BL/6-Ighb recipient mice 1 d after transfer was validated by flow cytometry.

Gene_expression (transferred) of IgMa in B cells

9) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.09 Pain Relevance 0

Selective immunoglobulin A deficiency (IgAD) is a primary immunodeficiency disease characterized by low levels (< 7 mg/dl) of serum immunoglobulin (Ig) A and normal serum levels of IgG and IgM.

Gene_expression (levels) of serum immunoglobulin associated with disease and immunodeficiency

10) Confidence 0.00 Published 2008 Journal J. Cutan. Pathol. Section Abstract Doc Link 18494827 Disease Relevance 1.23 Pain Relevance 0.11

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