INT35140

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Context Info
Confidence 0.32
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.78
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
synovial fluid 2
cleavage 1
platelet 1
urine 1
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 9 98.60 Very High Very High Very High
Inflammation 93 96.64 Very High Very High Very High
cocaine 140 90.72 High High
chemokine 9 88.80 High High
spinal inflammation 2 88.32 High High
cytokine 15 87.60 High High
rheumatoid arthritis 28 86.16 High High
antagonist 1 79.12 Quite High
peptic ulcer disease 1 74.76 Quite High
adenocard 2 60.72 Quite High
Disease Link Frequency Relevance Heat
Disease 193 99.80 Very High Very High Very High
INFLAMMATION 106 98.40 Very High Very High Very High
Coagulation Disorder 12 91.12 High High
Cryoglobulinemia 2 89.84 High High
Low Back Pain 2 88.32 High High
Systemic Lupus Erythematosus 4 87.36 High High
Rheumatoid Arthritis 28 86.16 High High
Thrombosis 17 85.24 High High
Acute Coronary Syndrome 8 83.56 Quite High
Mucocutaneous Lymph Node Syndrome 150 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibrinogen or fibrinogen degradation products were frequently present in synovial fluid cryoprecipitates but rarely in serum cryoprecipitates.
Protein_catabolism (degradation) of fibrinogen in synovial fluid
1) Confidence 0.32 Published 1981 Journal Arthritis Rheum. Section Abstract Doc Link 7317115 Disease Relevance 0.50 Pain Relevance 0.17
Fibrinogen or fibrinogen degradation products were frequently present in synovial fluid cryoprecipitates but rarely in serum cryoprecipitates.
Protein_catabolism (degradation) of Fibrinogen in synovial fluid
2) Confidence 0.32 Published 1981 Journal Arthritis Rheum. Section Abstract Doc Link 7317115 Disease Relevance 0.50 Pain Relevance 0.17
In contrast to previously described paraproteins, this patient's IgG appeared to inhibit the activity of thrombin per se rather than to interfere with fibrinogen cleavage or fibrin polymerization.
Protein_catabolism (cleavage) of fibrinogen in cleavage
3) Confidence 0.13 Published 1987 Journal Am. J. Hematol. Section Abstract Doc Link 3578266 Disease Relevance 0.40 Pain Relevance 0.07
The results indicate that cPUK exerts fibrinolytic efficacy without systemic plasminogen activation and breakdown of fibrinogen.
Protein_catabolism (breakdown) of fibrinogen
4) Confidence 0.11 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
Fibrinogen is degraded by MMP9 [39–41], and the fibrinogen degradation fragments have been shown to be biologically important molecules with numerous pro-inflammatory actions [42].
Protein_catabolism (degraded) of Fibrinogen associated with inflammation
5) Confidence 0.10 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.50 Pain Relevance 0.22
We reasoned that the generation of the SJIA urine biomarker peptides, including those derived from fibrinogen, may be an outcome of the actions of inflammatory mediators on protease expression and regulation, generating a disease-specific degradation pattern of source proteins, such as fibrinogen.
Protein_catabolism (degradation) of fibrinogen in urine associated with inflammatory mediators and disease
6) Confidence 0.09 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.58 Pain Relevance 0.25
The biochemical pathway for thrombolysis is such that tissue plasminogen activator coverts plaminogen to plasmin which in turn causes fibrinolysis by degrading fibrinogen and fibrin clots.
Protein_catabolism (degrading) of fibrinogen
7) Confidence 0.08 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.41 Pain Relevance 0.35
Fibrinogen is degraded by MMP9 [39–41], and the fibrinogen degradation fragments have been shown to be biologically important molecules with numerous pro-inflammatory actions [42].
Protein_catabolism (degradation) of fibrinogen associated with inflammation
8) Confidence 0.07 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.50 Pain Relevance 0.23
Abciximab, a platelet GP IIb/IIIa receptor blocker, was developed by Coller in 1985 and named 7E3.8 Abciximab is a chimeric human monoclonal antibody and binds to platelet surface GP IIb/IIIa receptors competitively with adhesive molecules, such as fibrinogen and von Willebrand factor, and blocks the final stage of platelet aggregation.9
Protein_catabolism (as) of fibrinogen in platelet
9) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615343 Disease Relevance 0.38 Pain Relevance 0.04

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