INT351540

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.44
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Prom1) plasma membrane (Prom1) cilium (Prom1)
Anatomy Link Frequency
macrophages 2
NSCs 2
Prom1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 96 92.92 High High
Central nervous system 8 5.00 Very Low Very Low Very Low
neurotrophin 3 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 242 99.56 Very High Very High Very High
Viral Infection 13 99.42 Very High Very High Very High
Infection 48 97.36 Very High Very High Very High
Cytomegalovirus Infection 56 96.68 Very High Very High Very High
Skin Cancer 6 93.28 High High
Neurodegenerative Disease 6 91.76 High High
Injury 2 80.76 Quite High
Glioblastoma 30 72.44 Quite High
Sensorineural Hearing Loss 1 65.28 Quite High
Cerebral Palsy 1 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another problem encountered during our studies is the decrease of CD133 expression in HCT116 tumor xenografts.
Negative_regulation (decrease) of Gene_expression (expression) of CD133 associated with cancer
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.71 Pain Relevance 0.12
A decrease of the CD133 expression levels in vivo might provide an explanation for the apparently smaller difference in CD133 expression in vivo compared to in vitro.
Negative_regulation (decrease) of Gene_expression (expression) of CD133
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.29 Pain Relevance 0
The lower signal to noise ratio of the HCT116 system was further reduced by downregulation of CD133 expression in vivo and non-specific antibody binding to tumor stroma macrophages.
Negative_regulation (downregulation) of Gene_expression (expression) of CD133 in macrophages associated with cancer
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.65 Pain Relevance 0.13
In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin.
Negative_regulation (loss) of Gene_expression (expressing) of CD133 in NSCs associated with viral infection
4) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.79 Pain Relevance 0

General Comments

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