INT351602

Context Info Confidence 0.02 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0

plasma membrane (TXK, ERBB2) nucleus (TXK, ERBB2) cytoplasm (TXK, ERBB2) cell proliferation (ERBB2) signal transduction (ERBB2) DNA binding (TXK)

TXK (Homo sapiens) ERBB2 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 5.00

Disease Link Frequency Relevance Heat Death 1 78.40 Stomach Cancer 47 78.00 Cancer 63 63.16 Breast Cancer 28 20.64 Adenocarcinoma 9 5.00 Esophageal Cancer 3 5.00 Disease 3 5.00 Cleidocranial Dysplasia 2 5.00 Recurrence 2 5.00 Atrophic Gastritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Compared to trastuzumab, lapatinib is a small molecule tyrosine kinase inhibitor (TKI) that targets both HER2 and epidermal growth factor receptor (EGFR/HER1) and can be administered orally.

tyrosine kinase Positive_regulation (targets) of HER2

1) Confidence 0.02 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3005843 Disease Relevance 0.58 Pain Relevance 0

General Comments

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