INT351974

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 11.10
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Stk11) aging (Agt) extracellular matrix organization (Agt)
protein complex (Stk11) cytoplasm (Stk11) cytosol (Stk11)
Anatomy Link Frequency
smooth muscle cells 2
carotid artery 2
Agt (Rattus norvegicus)
Stk11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 24 95.92 Very High Very High Very High
ketamine 12 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 252 100.00 Very High Very High Very High
Cancer 132 100.00 Very High Very High Very High
Vasculitis 72 100.00 Very High Very High Very High
Neointima 252 99.92 Very High Very High Very High
Carotid Artery Injuries 60 98.44 Very High Very High Very High
Necrosis 12 93.36 High High
Cardiovascular Disease 72 79.64 Quite High
Hypertrophy 12 67.52 Quite High
Increased Venous Pressure Under Development 24 61.08 Quite High
Apoptosis 12 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since LKB1 activity is dependent on post-translational modification, such as phosphorylation or acetylation, further study is needed to elucidate the molecular mechanisms of how Ang II increases LKB1 expression and decreases activity in VSMC and neointima formation.
Ang II Positive_regulation (increases) of Gene_expression (expression) of LKB1 associated with neointima
1) Confidence 0.51 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.81 Pain Relevance 0
Ang II augmented the increased expression of LKB1.
Ang II Positive_regulation (augmented) of Gene_expression (expression) of LKB1
2) Confidence 0.51 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.20 Pain Relevance 0
Ang II augmented the increased expression of LKB1 (Fig. 2F).
Ang II Positive_regulation (augmented) of Gene_expression (expression) of LKB1
3) Confidence 0.37 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.33 Pain Relevance 0.03
Although endogenous Ang II increased after vascular injury, the mechanisms of the interaction between Ang II, increased LKB1 expression and decreased LKB1 kinase activity is still elusive.
Ang II Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with vasculitis
4) Confidence 0.37 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.68 Pain Relevance 0
Ang II or balloon-injury increased the expression of LKB1 although the LKB1 activity was reduced.


Ang II Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with injury
5) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.25 Pain Relevance 0
Our data showed that Ang II induces LKB1 expression in VSMCs and that LKB1 expression increased after vascular injury.
Ang II Positive_regulation (induces) of Gene_expression (expression) of LKB1 associated with vasculitis
6) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.30 Pain Relevance 0
Ang II increased LKB1 expression in VSMCs and neointima.
Ang II Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with neointima
7) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.25 Pain Relevance 0
Ang II augmented LKB1 expression after the injury.
Ang II Positive_regulation (augmented) of Gene_expression (expression) of LKB1 associated with injury
8) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.31 Pain Relevance 0
Ang II increased LKB1 expression in a time-dependent manner and peaked at an Ang II concentration of 10-7 mole/L in VSMCs.
Ang II Positive_regulation (increased) of Gene_expression (expression) of LKB1
9) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.12 Pain Relevance 0
Angiotensin II increased LKB1 expression in vascular smooth muscle cells
Angiotensin II Positive_regulation (increased) of Gene_expression (expression) of LKB1 in smooth muscle cells
10) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.33 Pain Relevance 0.05
Ang II increased the LKB1 expression showed a bell shaped curve.
Ang II Positive_regulation (increased) of Gene_expression (expression) of LKB1
11) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.71 Pain Relevance 0.04
Ang II increases tumor suppressor serine/threonine kinase LKB1 expression in the VSMCs and neointima of the rat carotid artery injury model.
Ang II Positive_regulation (increases) of Gene_expression (expression) of kinase LKB1 in carotid artery associated with carotid artery injuries, cancer and neointima
12) Confidence 0.30 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.80 Pain Relevance 0

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