INT35209

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
thyroid 4
pituitary 2
midbrain 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 99.00 Very High Very High Very High
Somatostatin 3 98.92 Very High Very High Very High
midbrain 2 95.96 Very High Very High Very High
Raphe 4 94.60 High High
noradrenaline 1 90.88 High High
Dopamine 3 89.68 High High
Serotonin 2 88.64 High High
Lasting pain 2 86.32 High High
headache 1 82.56 Quite High
anesthesia 2 79.24 Quite High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 2 100.00 Very High Very High Very High
Nociception 1 90.24 High High
Pain 2 86.32 High High
Thyroid Disease 1 86.08 High High
Stress 2 85.36 High High
Adrenal Insufficiency 2 85.32 High High
Attention Deficit Hyperactivity Disorder 2 83.84 Quite High
Hyponatremia 1 83.68 Quite High
Headache 1 82.56 Quite High
Fibromyalgia 5 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only 2 out of 33 children without pituitary dysfunction did not present sufficient amounts of growth hormone following clonidine or sleep to exclude growth hormone deficiency to screen for growth hormone deficiency.
Positive_regulation (screen) of Negative_regulation (deficiency) of growth hormone in pituitary associated with growth hormone deficiency and clonidine
1) Confidence 0.48 Published 1984 Journal Monatsschr Kinderheilkd Section Abstract Doc Link 6392861 Disease Relevance 0.20 Pain Relevance 0.66
The administration of gamma-hydroxybutyrate (GHB) induced a consistent secretory episode of growth hormone (GH) in the morning followed by basal levels of secretion of GH for several hours.
Positive_regulation (induced) of Negative_regulation (episode) of growth hormone
2) Confidence 0.27 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0 Pain Relevance 0.25
A few months later, her pituitary function improved, with a significant increase in the adrenocorticotropic hormone level, normal values of basal thyroid-stimulating hormone, growth hormone, and gonadotropins and of their functional reserves, and only a slight elevation in the prolactin level.
Positive_regulation (increase) of Negative_regulation (values) of growth hormone in thyroid
3) Confidence 0.04 Published 1986 Journal JAMA Section Abstract Doc Link 3941502 Disease Relevance 0.34 Pain Relevance 0.08
Suppression of human growth hormone (GH)-releasing hormone-induced GH secretion in pentobarbital-anesthetized rats after electrical stimulation of the midbrain central gray and several raphe nuclei.
Positive_regulation (-releasing) of Negative_regulation (Suppression) of growth hormone in midbrain associated with midbrain and raphe
4) Confidence 0.04 Published 1988 Journal Endocrinology Section Title Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.34
In addition to its control of the adrenal hormones, CRH stimulates somatostatin secretion at the hypothalamic level, which, in turn, causes inhibition of growth hormone and thyroid-stimulating hormone at the pituitary level.
Positive_regulation (causes) of Negative_regulation (inhibition) of growth hormone in thyroid associated with somatostatin
5) Confidence 0.01 Published 2000 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 11084955 Disease Relevance 0.84 Pain Relevance 0.21

General Comments

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