INT352270

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.43
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tnf, GZMA) intracellular (Tnf) extracellular matrix organization (Tnf)
extracellular space (Tnf) signal transduction (Tnf) peptidase activity (GZMA)
Anatomy Link Frequency
Nerve 2
Tnf (Rattus norvegicus)
GZMA (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 22 93.36 High High
Somatostatin 4 90.86 High High
antidepressant 92 89.68 High High
adenocard 14 89.42 High High
Nerve growth factor 10 87.82 High High
Inflammation 10 65.48 Quite High
Hippocampus 18 58.40 Quite High
depression 26 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
monoamine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 36 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Apoptosis 28 98.72 Very High Very High Very High
Alzheimer's Dementia 16 98.42 Very High Very High Very High
INFLAMMATION 12 65.48 Quite High
Neurodegenerative Disease 12 19.04 Low Low
Depression 26 5.00 Very Low Very Low Very Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Tumor necrosis factor alpha Positive_regulation (induced) of Granzyme A in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
1) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.23 Pain Relevance 0.36
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Tumor necrosis factor alpha Positive_regulation (induced) of Granzyme A in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
2) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.19 Pain Relevance 0.19

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