INT352462

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnc) extracellular region (Tnc) proteinaceous extracellular matrix (Tnc)
molecular_function (Tnc)
Anatomy Link Frequency
trigeminal ganglia 2
Gse1 (Rattus norvegicus)
Tnc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 99.24 Very High Very High Very High
central sensitization 14 94.88 High High
Inflammatory stimuli 6 93.96 High High
Lasting pain 4 89.80 High High
allodynia 1 76.00 Quite High
Thermal hyperalgesia 1 74.88 Quite High
cytokine 5 71.24 Quite High
Pain 6 63.52 Quite High
Inflammation 14 60.48 Quite High
Snapping jaw 16 58.88 Quite High
Disease Link Frequency Relevance Heat
Nociception 14 98.16 Very High Very High Very High
INFLAMMATION 23 93.64 High High
Pain 10 89.80 High High
Neuropathic Pain 1 76.00 Quite High
Hyperalgesia 1 74.88 Quite High
Hypersensitivity 1 62.28 Quite High
Temporomandibular Joint Syndrome 13 58.88 Quite High
Ganglion Cysts 6 50.00 Quite Low
Inflammatory Pain 1 49.60 Quite Low
Repression 1 30.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, GSE elevated expression of proteins in trigeminal ganglia and TNC known to decrease neuronal excitability and suppressed CFA-induced expression of several proteins implicated in peripheral and central sensitization.
GSE Positive_regulation (elevated) of Gene_expression (expression) of TNC in trigeminal ganglia associated with central sensitization and neuronal excitability
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.75 Pain Relevance 0.64

General Comments

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