INT352614

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Context Info
Confidence 0.19
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2, Trp53) enzyme binding (Mdm2, Trp53) protein complex assembly (Mdm2, Trp53)
protein complex (Mdm2, Trp53) cytoplasm (Mdm2, Trp53) cytosol (Mdm2, Trp53)
Mdm2 (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 72 87.96 High High
Breast Cancer 3 86.48 High High
Aging 7 84.56 Quite High
Apoptosis 26 84.00 Quite High
Brain Tumor 60 72.56 Quite High
Glioma 45 68.08 Quite High
Colon Cancer 1 63.20 Quite High
Death 3 27.56 Quite Low
Shock 1 8.84 Low Low
Glioblastoma 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nutlin-3 is a compound that disrupts the binding between MDM2 and p53 leading to activation and accumulation of free p53 [153].
Negative_regulation (disrupts) of MDM2 Binding (binding) of p53
1) Confidence 0.19 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.16 Pain Relevance 0

General Comments

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