INT352758

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.63 Pain Relevance 0.08

plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1) kinase activity (Prkd1) cytoplasm (Prkd1)

Anatomy Link Frequency neutrophil 4 Sms (Mus musculus) Prkd1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 80.80 imagery 22 5.00 ketamine 4 5.00 metalloproteinase 2 5.00 Cholecystokinin 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Fungal Infection 38 82.60 Sprains And Strains 12 61.52 Cryptococcus Infection 10 59.44 Infection 66 46.76 Communicable Diseases 2 39.00 Candida Infection 10 5.00 Urological Neuroanatomy 4 5.00 Granuloma 4 5.00 Targeted Disruption 4 5.00 Hypoxia 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also provide evidence supporting a mechanism by which SMS regulates neutrophil killing against C. neoformans through the production of DAG and the consequent activation of protein kinase D (PKD).

SMS Regulation (regulates) of Positive_regulation (activation) of protein kinase D in neutrophil

1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.31 Pain Relevance 0.04

We also provide evidence supporting a mechanism by which SMS regulates neutrophil killing against C. neoformans through the production of DAG and the consequent activation of protein kinase D (PKD).

SMS Regulation (regulates) of Positive_regulation (activation) of PKD in neutrophil

2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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