INT35284

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 30
Disease Relevance 5.64
Pain Relevance 10.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm1) plasma membrane (Chrm1) signal transducer activity (Chrm1)
Anatomy Link Frequency
hippocampus 2
spinal 1
brain 1
N1E-115 1
Chrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 417 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
long-term potentiation 1071 99.90 Very High Very High Very High
allodynia 2 99.90 Very High Very High Very High
Hippocampus 212 99.86 Very High Very High Very High
Kinase C 79 99.80 Very High Very High Very High
antinociception 4 99.36 Very High Very High Very High
Clonidine 5 99.30 Very High Very High Very High
Pyramidal cell 317 99.28 Very High Very High Very High
Eae 6 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.90 Very High Very High Very High
Disease 395 99.30 Very High Very High Very High
INFLAMMATION 40 98.96 Very High Very High Very High
Diabetes Mellitus 62 98.92 Very High Very High Very High
Neuroblastoma 2 98.92 Very High Very High Very High
Sprains And Strains 45 98.68 Very High Very High Very High
Toxicity 30 97.52 Very High Very High Very High
Alzheimer's Dementia 24 96.12 Very High Very High Very High
Apoptosis 58 94.88 High High
Shock 3 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M1 receptor agonist activity is not a requirement for muscarinic antinociception.
Neg (not) Positive_regulation (requirement) of M1 receptor associated with antinociception, analgesic and agonist
1) Confidence 0.67 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9152396 Disease Relevance 0.09 Pain Relevance 0.71
Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.
Positive_regulation (activation) of M1 receptor in spinal associated with allodynia, diabetes mellitus, clonidine and intrathecal
2) Confidence 0.52 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15556139 Disease Relevance 0.66 Pain Relevance 1.33
Therefore, our data support the conclusion that SK channels can regulate the induction of LTP and provide evidence that SK channel function is controlled by activation of M1 receptors.
Positive_regulation (activation) of M1 associated with long-term potentiation
3) Confidence 0.47 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.30
Our data show that M1 receptor activation prolongs the NMDAR-mediated component of the EPSP during LTP induction, and we suggest this is the mechanism for the facilitation of LTP (Figure 5).
Positive_regulation (activation) of M1 receptor associated with long-term potentiation
4) Confidence 0.47 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.21
The detailed mechanism and the molecular interactions that connect M1 receptor activation to SK channel inhibition are currently unknown.
Positive_regulation (activation) of M1 receptor
5) Confidence 0.47 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.26
In the presence of 77-LH-28-1, the amount of LTP was increased to 135% ± 7% (n = 6, p < 0.05), demonstrating that M1 receptor activation facilitates LTP in agreement with previous reports (Ovsepian et al., 2004; Shinoe et al., 2005).
Positive_regulation (activation) of M1 receptor associated with long-term potentiation
6) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.46
In the present study, we show that SK channels mediating a component of the IAHP are directly modulated by M1 receptors (Figure 6) and that blockade of SK channels with apamin occludes the action of M1 receptor activation on NMDAR function (Figure 6) and LTP induction (Figure 8).
Positive_regulation (activation) of M1 receptor associated with long-term potentiation
7) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.40
These data argue strongly against a direct action of M1 receptor activation on NMDARs, such as has been suggested in previous reports (Aramakis et al., 1999; Harvey et al., 1993; Marino et al., 1998; Markram and Segal, 1990, 1992).
Positive_regulation (activation) of M1 receptor
8) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.11 Pain Relevance 0.16
We next investigated the role of selective M1 receptor activation on LTP induced by a theta burst pairing (TBP) protocol.
Spec (investigated) Positive_regulation (activation) of M1 receptor associated with long-term potentiation
9) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.19 Pain Relevance 0.41
We next tested whether the release of endogenous acetylcholine from cholinergic fibers in the hippocampus could activate M1 receptors on CA1 pyramidal cells and facilitate the induction of LTP.
Positive_regulation (activate) of M1 in hippocampus associated with pyramidal cell, long-term potentiation and hippocampus
10) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.54
While this may indeed be the case, our data indicate that KCNQ channels do not mediate the facilitation of NMDAR function induced by M1 receptor activation since blockade of KCNQ channels with XE-991 did not prevent the actions of M1 receptor activation on NMDAR function (Figure 6).
Positive_regulation (activation) of M1 receptor
11) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.05 Pain Relevance 0.11
These data indicate that membrane depolarization and increased input resistance seen in the presence of XE-991 are not sufficient to occlude the effects of M1 receptor activation on NMDAR function.
Positive_regulation (activation) of M1 receptor
12) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.06
This indicates that the depolarizing action of acetylcholine is due to M1 receptor activation, but the effects on synaptic transmission are due to activation of nicotinic receptors or mAChRs other than M1.
Positive_regulation (activation) of M1 receptor
13) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.24 Pain Relevance 0.34
M1 receptor activation inhibits SK channel function ?
Positive_regulation (activation) of M1 receptor
14) Confidence 0.34 Published 2010 Journal Neuron Section Abstract Doc Link PMC3003154 Disease Relevance 0.06 Pain Relevance 0.45
While this may indeed be the case, our data indicate that KCNQ channels do not mediate the facilitation of NMDAR function induced by M1 receptor activation since blockade of KCNQ channels with XE-991 did not prevent the actions of M1 receptor activation on NMDAR function (Figure 6).
Positive_regulation (activation) of M1 receptor
15) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.06 Pain Relevance 0.10
The depolarization and increase in input resistance caused by the activation of M1 receptors could also enhance NMDAR activation during synaptic transmission and in particular during TBP.
Positive_regulation (activation) of M1
16) Confidence 0.32 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.08
N-methyl-D-aspartate receptor (NMDAR) opening during theta burst stimulation was enhanced by M1 receptor activation, indicating this is the mechanism for LTP facilitation.
Positive_regulation (activation) of M1 receptor associated with nmda receptor and long-term potentiation
17) Confidence 0.32 Published 2010 Journal Neuron Section Abstract Doc Link PMC3003154 Disease Relevance 0.08 Pain Relevance 0.46
Therefore, the regulation of SK channel function by M1 receptor activation may be a critical step in the induction of hippocampal LTP in vivo.


Positive_regulation (activation) of M1 receptor associated with long-term potentiation
18) Confidence 0.32 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.41 Pain Relevance 0.37
Similarly, release of acetylcholine by stimulation of cholinergic fibers facilitates LTP via activation of M1 receptors.
Positive_regulation (activation) of M1 associated with long-term potentiation
19) Confidence 0.32 Published 2010 Journal Neuron Section Abstract Doc Link PMC3003154 Disease Relevance 0.08 Pain Relevance 0.44
Muscarinic acetylcholine receptor (mAChR) activation in cortical and hippocampal networks acute brain slices induces synchronized activity and network oscillations.
Positive_regulation (activation) of Muscarinic acetylcholine receptor in brain
20) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.27 Pain Relevance 0.10

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