INT35292

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.30
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) response to stress (C5)
Anatomy Link Frequency
finger 1
C5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 229 97.64 Very High Very High Very High
qutenza 6 97.32 Very High Very High Very High
Inflammation 19 96.32 Very High Very High Very High
shoulder pain 1 93.44 High High
headache 2 92.84 High High
Arthritis 45 5.00 Very Low Very Low Very Low
cva 17 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 101 100.00 Very High Very High Very High
Meningitis 9 99.42 Very High Very High Very High
Disease 127 98.24 Very High Very High Very High
Rheumatoid Arthritis 232 97.64 Very High Very High Very High
INFLAMMATION 24 96.32 Very High Very High Very High
Polymyositis 1 96.00 Very High Very High Very High
Muscle Weakness 1 94.28 High High
Shoulder Pain 1 93.44 High High
Headache 2 92.84 High High
Weight Loss 1 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation revealed meningococcal meningitis due to serogroup W135 and a C5 deficiency.
Negative_regulation (deficiency) of C5 associated with meningitis
1) Confidence 0.43 Published 1988 Journal Arch. Intern. Med. Section Abstract Doc Link 3132125 Disease Relevance 0.82 Pain Relevance 0.19
RESULTS: There was excellent visualization of the C-3, C-4, C-5, C-6 and C-7 transverse processes in all cases.
Negative_regulation (visualization) of C-5
2) Confidence 0.41 Published 2010 Journal Surg Radiol Anat Section Body Doc Link 20082079 Disease Relevance 0 Pain Relevance 0
Further studies in mice identifying C5 as a candidate gene and showing that C5 deficiency results in lower incidence and less-severe disease course support the role of this gene in inflammation [7,11].
Negative_regulation (deficiency) of C5 associated with inflammation and disease
3) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.68 Pain Relevance 0.26
We chose 40 polymorphisms spanning TRAF1/C5 and their flanking genes PHD finger protein 19 (PHF19) and centrosomal protein 110 kDa (CEP110) for this study (Table 1).
Negative_regulation (spanning) of C5 in finger
4) Confidence 0.38 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.27 Pain Relevance 0.10
The mannitol C2 and C5 were decreased in subjects with chronic cough compared to healthy controls demonstrating a heightened response to mannitol (Table 1 and Figure 1).
Negative_regulation (decreased) of C5 associated with cough
5) Confidence 0.24 Published 2008 Journal Cough Section Body Doc Link PMC2596167 Disease Relevance 2.25 Pain Relevance 0.15
Our study defines the TRAF1/C5 as a novel genetic region present in the human genome that predisposes to RA.
Negative_regulation (defines) of C5 associated with rheumatoid arthritis
6) Confidence 0.17 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.87 Pain Relevance 0.17
They act at different levels of the complement cascade (Figure 3): CD55 controls early complement activation, inhibiting C3 and C5 convertases (Burge et al 1981; Medof et al 1984), while CD59 interferes with the terminal effector complement, blocking the incorporation of C9 onto the C5b-C8 complex, forming the membrane attack complex (MAC) (Shin et al 1986; Zalman et al 1986).
Negative_regulation (inhibiting) of C5
7) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.41 Pain Relevance 0

General Comments

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