INT353223

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 3.11
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Neurog3) cytoplasm (Neurog3)
Anatomy Link Frequency
spinal cord 3
grid 1
Neurog3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 364 99.12 Very High Very High Very High
Serotonin 117 97.52 Very High Very High Very High
Inflammatory response 13 90.36 High High
Inflammation 13 86.72 High High
hyperpathia 13 80.56 Quite High
allodynia 26 79.80 Quite High
Neuropathic pain 13 64.56 Quite High
Eae 13 59.60 Quite High
anesthesia 26 46.16 Quite Low
isoflurane 13 40.80 Quite Low
Disease Link Frequency Relevance Heat
Spinal Cord Compression 104 99.12 Very High Very High Very High
Spinal Cord Injury 221 98.64 Very High Very High Very High
INFLAMMATION 26 90.00 High High
Injury 182 85.88 High High
Hyperalgesia 13 80.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 79.88 Quite High
Neuropathic Pain 39 79.80 Quite High
Keloid Scars 13 37.12 Quite Low
Fibrosis 13 36.56 Quite Low
Pressure And Volume Under Development 13 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, not only does a transient expression of Ngn2 suffice to achieve motor functional recovery but also functional benefits obviously do not result from replacement of lost cells.
Gene_expression (expression) of Ngn2
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.51 Pain Relevance 0.41
To conclude, transplantation of short term surviving hENPs that express Ngn2 restores weight support and grid walk after severe spinal cord compression.
Gene_expression (express) of Ngn2 in grid associated with spinal cord
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.43 Pain Relevance 0.30
With the objective of translation to clinics we have chosen a paradigm of delayed grafting, i.e., one week after lesion, in a severe model of spinal cord compression in adult rats. hENPs were either naïve or engineered to express Neurogenin 2 (Ngn2).
Gene_expression (express) of Ngn2 in spinal cord associated with spinal cord
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012721 Disease Relevance 0.40 Pain Relevance 0.20
Behavioral recovery was compared in four groups of animals: 1) injured-only animals, 2) injured animals grafted with naïve hENPs transduced with a GFP expressing lentiviral vector, 3) animals grafted with hENPs genetically modified to express Ngn2 with an integrating (Trip-PGK-Ngn2) vector, 4) animals grafted with a non-integrating (Ni-Trip-PGK-Ngn2) lentiviral vector [15].
Gene_expression (express) of Ngn2
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.14 Pain Relevance 0.16
In both cases cells transduced to express Ngn2 were co-transduced with the respective (Trip or Ni-Trip) PGK-GFP vectors.


Gene_expression (express) of Ngn2
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.17 Pain Relevance 0.05
93.6 (arbitrary units) in the non-integrating-Ngn2-hENPs and naïve-hENPs grafted groups) (Figure 2C).
Gene_expression (integrating) of Ngn2
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.09 Pain Relevance 0.07
Since hENPs were not detectable 4 weeks after grafting, transitory expression of Ngn2 appears sufficient to achieve motor recovery and to permit axonal regeneration.
Gene_expression (expression) of Ngn2
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012721 Disease Relevance 0.34 Pain Relevance 0.22
With the aim of translation to the clinic, we explored the transplantation potential of hENPs either naïve, or engineered to express Ngn2 in a severe model of spinal cord compression in adult rats.
Gene_expression (express) of Ngn2 in spinal cord associated with spinal cord
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.10 Pain Relevance 0.17
Moreover, we evidence that hENPs transduced with a non-integrating lentiviral vector to express Ngn2 induce similar recovery than those transduced with an integrating vector.
Gene_expression (express) of Ngn2
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.16 Pain Relevance 0.18
We show that transplantation of hENPs transduced to express Ngn2 fully restore weight support and improve functional motor recovery after severe spinal cord compression at thoracic level.
Gene_expression (express) of Ngn2 in spinal cord associated with spinal cord
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012721 Disease Relevance 0.38 Pain Relevance 0.21
We report here that hENPs expressing Ngn2 induce a functional motor recovery associated with a partial restoration of serotonin fibers and appropriate location of serotonin receptors below the lesion site.
Gene_expression (expressing) of Ngn2 associated with serotonin
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.15 Pain Relevance 0.20
Conclusions and Significance
Transplantation and short-term survival of Ngn2-expressing hENPs restore weight support after SCI and partially restore serotonin fibers density and 5HT1A receptor pattern caudal to the lesion. 
Gene_expression (expressing) of Ngn2 associated with spinal cord injury and serotonin
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012721 Disease Relevance 0.24 Pain Relevance 0.19
For all other tests, animals grafted with persistent (integrating vector) and transient (non-integrating vector) Ngn2 expression recovered similarly (Figure 1).
Gene_expression (expression) of Ngn2
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0 Pain Relevance 0.05

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