INT353269

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tgif1) DNA binding (Tgif1)
Tgif1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 50 90.32 High High
fibrosis 14 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keloid Scars 8 94.32 High High
INFLAMMATION 50 90.32 High High
Burns 20 75.68 Quite High
Fibrosis 16 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Internal Fibrosis 2 5.00 Very Low Very Low Very Low
Conjunctivitis 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we postulate that suppression of myofibroblasts by TSA is due to the suppression of Smad activity by the upregulation of Smad7 and TGIF and inhibition of extracellular deposition of fibronectin.
Negative_regulation (suppression) of Positive_regulation (upregulation) of TGIF
1) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.32 Pain Relevance 0.08
Moreover, it is also likely that upregulation of TGIF might have suppressed the Smad-dependent gene expression at the gene promoter level.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of TGIF
2) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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