INT353452

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.89 Pain Relevance 0.34

nucleoplasm (BRCA1) chromosome segregation (BRCA1) Golgi apparatus (AGRP) intracellular (BRCA1) enzyme binding (BRCA1) DNA binding (BRCA1)

AGRP (Homo sapiens) BRCA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 72 100.00 Inflammatory marker 2 97.28 Central nervous system 36 85.88 Inflammation 74 82.68 Inflammatory response 12 5.00 Neuritis 4 5.00 headache 4 5.00 fibrosis 2 5.00 chemokine 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Immune Reconstitution Inflammatory Syndrome 444 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 96 98.82 INFLAMMATION 78 97.28 Cryptococcal Meningitis 204 92.48 Cryptococcus Infection 14 90.64 Death 34 89.84 Fungal Infection 4 38.08 Infection 22 5.00 Mycobacterial Infection 12 5.00 Recurrence 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similar to a recent ACTG (AIDS Clinical Trial Group) a5164 trial, in our study timing of ART initiation was not associated with IRIS [54].

ART Binding (associated) of IRIS associated with immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection

1) Confidence 0.00 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 2.52 Pain Relevance 0.12

Notably, increased pre-ART levels of IL-17, often viewed as a proinflammatory cytokine, were also associated with future IRIS.

pre-ART Binding (associated) of IRIS associated with immune reconstitution inflammatory syndrome and cytokine

2) Confidence 0.00 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.37 Pain Relevance 0.22

General Comments

This test has worked.