INT3536

Context Info Confidence 0.19 First Reported 1976 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 0.93 Pain Relevance 0.70

cell differentiation (Nrp1) cytosol (Nrp1) cell adhesion (Nrp1) plasma membrane (Nrp1)

Anatomy Link Frequency growth cone 1 Nrp1 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 49 99.74 local anesthetic 7 99.24 Inflammation 7 62.64 Antinociceptive 1 19.72 Pain 1 9.08 substance P 8 5.00 c fibre 3 5.00 qutenza 3 5.00 cytokine 2 5.00 Antihistamine 2 5.00

Disease Link Frequency Relevance Heat Eczema 108 99.48 Shock 1 96.88 Pruritus 24 79.12 Acanthosis 2 68.64 INFLAMMATION 5 62.64 Skin Diseases 3 46.16 Congenital Anomalies 4 18.96 Disease 4 5.00 Hypersensitivity 4 5.00 Erythema 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the combination therapy of Sema3A with anti-NGF antibody may not be justified for AD, because NGF is known to increase the expression levels of NRP-157 and to augment the effect of Sema3A to induce axon repulsion (or growth cone collapse) of dorsal root ganglia neurons.58 Further studies should be required to elucidate the mechanism of action of Sema3A on AD.

Positive_regulation (increase) of NRP-157 in growth cone associated with nerve growth factor, shock and eczema

1) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.93 Pain Relevance 0.22

Cell shape changes and transmembrane receptor uncoupling induced by tertiary amine local anesthetic.

Positive_regulation (induced) of transmembrane receptor associated with local anesthetic

2) Confidence 0.07 Published 1976 Journal J. Supramol. Struct. Section Title Doc Link 792570 Disease Relevance 0 Pain Relevance 0.48

General Comments

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