INT35368

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Context Info
Confidence 0.53
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 4.68
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tk1) kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
uterine 1
heart 1
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 99.98 Very High Very High Very High
opioid receptor 6 99.24 Very High Very High Very High
palliative 1 99.12 Very High Very High Very High
Kinase C 12 98.60 Very High Very High Very High
antagonist 4 90.16 High High
ischemia 3 90.08 High High
Enkephalin 3 86.76 High High
MU agonist 3 85.36 High High
Bioavailability 2 83.92 Quite High
addiction 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 3 97.60 Very High Very High Very High
Cancer 21 93.40 High High
Adhesions 2 92.92 High High
Infection 16 91.52 High High
Herpes Zoster 32 91.08 High High
Cv Unclassified Under Development 3 90.08 High High
Sprains And Strains 4 86.76 High High
Hypoalbuminemia 2 83.76 Quite High
Hematological Disease 4 83.08 Quite High
Reprotox - General 3 1 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TK activity increases during G1 and early S phases of the cell cycle and is often used as a marker of cell proliferation.
Positive_regulation (increases) of TK
1) Confidence 0.53 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.23 Pain Relevance 0
We investigated the possibility that opioids activate a tyrosine kinase (TK) that mediates cardioprotection in an in vivo rat model of myocardial infarction.
Spec (possibility) Positive_regulation (activate) of TK associated with opioid and myocardial infarction
2) Confidence 0.49 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0.19 Pain Relevance 0.36
The levels of TS mRNA and TK mRNA were determined by densitometry from photographs taken with an image analyzer (AE6920-MF Densitograph, ATTO, Tokyo), and are expressed as a ratio of the mRNA level of ?
Positive_regulation (levels) of TK mRNA
3) Confidence 0.38 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.06 Pain Relevance 0
These data suggest that a TK, but most likely not an Src/EGF receptor TK, is important in cardioprotection via opioid receptor stimulation and that the pathway for TK activation is downstream from or parallel to PKC activation in the in situ rat heart since genistein could not affect PKC translocation of selective isoforms induced by TAN-67 and assessed by immunohistochemistry.
Positive_regulation (activation) of TK in heart associated with kinase c and opioid receptor
4) Confidence 0.35 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0 Pain Relevance 0.47
Interestingly, the selective Src/epidermal growth factor (EGF) receptor TK inhibitor, lavendustin A, did not abolish TAN-67-induced cardioprotection (22.1 +/- 6.8).
Positive_regulation (selective) of TK
5) Confidence 0.31 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0.15 Pain Relevance 0.49
Thirty hours after administration of E2 (1.0 micrograms/kg) alone, uterine wet weight and TK activity were elevated 2.4- and 21-fold, respectively, over controls.
Positive_regulation (elevated) of TK in uterine
6) Confidence 0.22 Published 1988 Journal J Ethnopharmacol Section Abstract Doc Link 3143030 Disease Relevance 0.29 Pain Relevance 0.10
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Positive_regulation (Changes) of TK associated with palliative
7) Confidence 0.07 Published 2005 Journal Anticancer Res. Section Title Doc Link 16033109 Disease Relevance 0.09 Pain Relevance 0.10
As with aciclovir itself, all of these drugs are dependent on the virus-encoded thymidine kinase (TK) for their intracellular activation (phosphorylation), and, upon conversion to their triphosphate form, they act as inhibitors/alternative substrate of the viral DNA polymerase.
Positive_regulation (dependent) of TK
8) Confidence 0.05 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 1.45 Pain Relevance 0.14
As with aciclovir itself, all of these drugs are dependent on the virus-encoded thymidine kinase (TK) for their intracellular activation (phosphorylation), and, upon conversion to their triphosphate form, they act as inhibitors/alternative substrate of the viral DNA polymerase.
Positive_regulation (activation) of TK
9) Confidence 0.05 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 1.42 Pain Relevance 0.14
Binding of these ligands results in EGFR dimerization, which leads to high-affinity ligand binding, activation of the intrinsic protein tyrosine kinase (TK) activity, and tyrosine autophosphorylation.
Positive_regulation (activation) of TK
10) Confidence 0.01 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.35 Pain Relevance 0
Activation of the intracellular protein TK leads to recruitment and phosphorylation of several intracellular substrates, triggering a variety of cellular responses including cell division, survival, motility, invasion, adhesion, and cellular repair6,7.
Positive_regulation (Activation) of TK associated with adhesions
11) Confidence 0.01 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.45 Pain Relevance 0

General Comments

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