INT353690

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.17 Pain Relevance 1.01

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2) plasma membrane (Grin2b) embryo development (Grin2b) response to stress (Ca2)

Anatomy Link Frequency neuronal 1 Grin2b (Rattus norvegicus) Ca2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat nMDA receptor 66 100.00 Glutamate 36 100.00 ischemia 110 98.86 bDMF 6 91.00 Glutamate receptor 6 5.00 isoflurane 6 5.00 adenocard 4 5.00 tetrodotoxin 2 5.00 Central nervous system 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Injury 18 99.16 Brain Hemorrhage 76 98.86 Death 10 93.96 Parkinson's Disease 2 93.36 Cv Unclassified Under Development 30 74.48 Apoptosis 2 68.88 Infarction 6 5.00 Hypoxia 6 5.00 Middle Cerebral Artery Infarction 4 5.00 Cv General 4 Under Development 4 5.00

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Anatomy

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Speculation

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The most remarkable decrease of neural (NeuN) and astroglial protein (GFAP) 24 h after focal cerebral ischemia supports evidence demonstrating that increased NCX1 and NR2B-containing NMDA receptor is closely associated with Ca2+-dependent neuronal injury in the penumbra.

NR2B-containing Binding (associated) of Ca2 in neuronal associated with brain hemorrhage, nmda receptor, ischemia and injury

1) Confidence 0.14 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.58 Pain Relevance 0.33

Significant increase of NR2A 3 h after focal cerebral ischemia might couple with the compensatory response to diminish the Ca2+ which is associated with lower affinity for glutamate and considerably shorter offset decay time for Ca2+ compared with those of NR2B-containing NMDA receptors.

NR2B-containing Binding (associated) of Ca2 associated with brain hemorrhage, glutamate, nmda receptor and ischemia

2) Confidence 0.14 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.59 Pain Relevance 0.67

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