INT354719

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 2.34
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC1, Pick1) mitochondrion (Pick1) transport (ASIC1)
Golgi apparatus (Pick1) enzyme binding (Pick1) protein complex (Pick1)
ASIC1 (Homo sapiens)
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 110 88.64 High High
Glutamate 10 76.00 Quite High
Glutamate receptor 10 67.08 Quite High
Pain 10 47.32 Quite Low
Multiple sclerosis 10 45.12 Quite Low
ischemia 10 44.00 Quite Low
Kinase C 10 31.20 Quite Low
Central nervous system 10 30.04 Quite Low
imagery 30 5.00 Very Low Very Low Very Low
Dopamine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 60 99.24 Very High Very High Very High
Disease 40 96.96 Very High Very High Very High
Brain Injury 10 90.72 High High
Death 80 86.08 High High
Acidosis 40 80.32 Quite High
Male Infertility 10 78.84 Quite High
Apoptosis 10 57.44 Quite High
Pain 10 47.32 Quite Low
Convulsion 10 46.72 Quite Low
Demyelinating Disease 10 45.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the BAR domain is not required for PICK1 to interact with ASIC1a but is necessary for it to cluster ASIC1a.


ASIC1a Binding (interact) of PICK1
1) Confidence 0.40 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.27 Pain Relevance 0
Furthermore, the interaction of PICK1 with ASIC1a was found to be regulated by protein kinases [40,41].
ASIC1a Binding (interaction) of PICK1
2) Confidence 0.40 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0.03
Previous studies show that ASIC1a interacts with PICK1 and this interaction changes the subcellular clustering of ASIC1a [38,39].
ASIC1a Binding (interacts) of PICK1
3) Confidence 0.40 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.13 Pain Relevance 0.03
The interaction of ASIC1a and PICK1 is mediated by the C-terminus of ASIC1a and the PDZ domain of PICK1.
ASIC1a Binding (interaction) of PICK1
4) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.18 Pain Relevance 0.03
Interestingly, ASIC1a interacts with PICK1 (protein interacting with C-kinase 1), an intracellular protein that regulates trafficking of several membrane proteins.
ASIC1a Binding (interacts) of PICK1
5) Confidence 0.30 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0.04
Interestingly, ASIC1a interacts with PICK1 (protein interacting with C-kinase 1), an intracellular protein that regulates trafficking of several membrane proteins.
ASIC1a Binding (interacting) of PICK1
6) Confidence 0.30 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0.04
Consistent with earlier results [38,39], a direct interaction between PICK1 and ASIC1a through the PDZ interaction is important.
ASIC1a Binding (interaction) of PICK1
7) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.49 Pain Relevance 0.09
These data indicate that PICK1 enhanced ASIC1a-mediated cell toxicity and this enhancement is dependent on PICK1's lipid binding ability and its interaction with ASIC1a.


ASIC1a Binding (interaction) of PICK1 associated with toxicity
8) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.58 Pain Relevance 0.06
The interaction of ASIC1a and PICK1 is mediated by the C-terminus of ASIC1a and the PDZ domain of PICK1.
ASIC1a Binding (interaction) of PICK1
9) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.12 Pain Relevance 0.03
To test if PICK1's effect on ASIC1a surface expression requires their interaction, we also examined the effect of a PICK1 PDZ domain mutant, KD-AA, which has two critical residues in the PDZ domain of PICK1, Lys27 and Asp28, mutated to alanine and renders the mutated PICK1 unable to interact with ASIC1a [38,39].
ASIC1a Neg (unable) Binding (interact) of PICK1
10) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04

General Comments

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