INT354721

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.10
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pick1, ASIC1) transport (ASIC1) mitochondrion (Pick1)
Golgi apparatus (Pick1) enzyme binding (Pick1) protein complex (Pick1)
Pick1 (Mus musculus)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 8 88.56 High High
ASIC 88 82.00 Quite High
Glutamate receptor 8 45.32 Quite Low
Pain 8 25.56 Quite Low
Multiple sclerosis 8 23.36 Low Low
ischemia 8 22.24 Low Low
Central nervous system 8 8.28 Low Low
imagery 24 5.00 Very Low Very Low Very Low
Dopamine 16 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 64 95.32 Very High Very High Very High
Acidosis 32 92.88 High High
Toxicity 48 91.12 High High
Disease 32 90.32 High High
Male Infertility 8 57.08 Quite High
Apoptosis 8 50.56 Quite High
Pain 8 25.56 Quite Low
Convulsion 8 24.96 Low Low
Demyelinating Disease 8 23.36 Low Low
Brain Injury 8 23.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that both the PDZ and BAR domains are required for PICK1 to regulate ASIC1a surface expression.


PICK1 Regulation (regulate) of Gene_expression (expression) of ASIC1a
1) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Given that PICK1 regulates trafficking of several membrane proteins, and that PICK1 directly interacts with ASIC1, we hypothesize here that PDZ and BAR domains of PICK1 cooperatively regulate ASIC1a surface expression.
PICK1 Regulation (regulate) of Gene_expression (expression) of ASIC1a
2) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.23 Pain Relevance 0
Both the PDZ and BAR domains are required for PICK1's effect on surface expression of ASIC1a, we therefore asked if the PDZ and BAR domain mutants abolish the potentiation effect of PICK1 on acid-induced cell death.
PICK1 Regulation (effect) of Gene_expression (expression) of ASIC1a associated with death
3) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.45 Pain Relevance 0
To test if PICK1's effect on ASIC1a surface expression requires their interaction, we also examined the effect of a PICK1 PDZ domain mutant, KD-AA, which has two critical residues in the PDZ domain of PICK1, Lys27 and Asp28, mutated to alanine and renders the mutated PICK1 unable to interact with ASIC1a [38,39].
PICK1 Regulation (effect) of Gene_expression (expression) of ASIC1a
4) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
Our results showed that PICK1 regulates cell-surface expression of ASIC1a in a lipid binding-dependent manner.
PICK1 Regulation (regulates) of Gene_expression (expression) of ASIC1a
5) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.24 Pain Relevance 0
This result indicates that lipid binding is required for PICK1-regulated surface expression of ASIC1a.
PICK1 Regulation (regulated) of Gene_expression (expression) of ASIC1a
6) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
However, whether PICK1 regulates ASIC1a surface expression remains unknown.


PICK1 Spec (whether) Regulation (regulates) of Gene_expression (expression) of ASIC1a
7) Confidence 0.22 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.18 Pain Relevance 0.04
We therefore asked whether the effect of PICK1 on ASIC1a surface expression is also dependent on the BAR domain of PICK1.
PICK1 Spec (whether) Regulation (effect) of Gene_expression (expression) of ASIC1a
8) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04

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