INT354724

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) endoplasmic reticulum (Bfar)
plasma membrane (ASIC1) molecular_function (Bfar)
Bfar (Mus musculus)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 62.72 Quite High
Glutamate receptor 2 45.92 Quite Low
Pain 2 26.16 Quite Low
Multiple sclerosis 2 23.96 Low Low
ischemia 2 22.84 Low Low
Central nervous system 2 8.88 Low Low
ASIC 22 5.64 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 8 86.88 High High
Toxicity 12 85.12 High High
Male Infertility 2 57.68 Quite High
Disease 8 29.04 Quite Low
Pain 2 26.16 Quite Low
Convulsion 2 25.56 Quite Low
Demyelinating Disease 2 23.96 Low Low
Cv Unclassified Under Development 2 22.84 Low Low
Neurological Disease 2 22.08 Low Low
Anxiety Disorder 2 18.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that both the PDZ and BAR domains are required for PICK1 to regulate ASIC1a surface expression.


BAR Regulation (regulate) of Gene_expression (expression) of ASIC1a
1) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Given that PICK1 regulates trafficking of several membrane proteins, and that PICK1 directly interacts with ASIC1, we hypothesize here that PDZ and BAR domains of PICK1 cooperatively regulate ASIC1a surface expression.
BAR Regulation (regulate) of Gene_expression (expression) of ASIC1a
2) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.23 Pain Relevance 0

General Comments

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