INT3552

Context Info Confidence 0.41 First Reported 1975 Last Reported 1999 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.39 Pain Relevance 0.60

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren) intracellular (Ren) response to stress (Ren)

Anatomy Link Frequency plasma 3 liver 2 blood 1 Ren (Rattus norvegicus)

Pain Link Frequency Relevance Heat fluoxetine 5 93.76 sSRI 1 93.28 headache 1 85.68 Serotonin 10 77.28 adenocard 1 50.48 bradykinin 1 50.04 Clonidine 1 49.56 midbrain 1 25.00

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 3 99.28 Anxiety Disorder 3 98.44 Appetite Loss 4 97.52 Adenoma 1 90.56 Hamartoma 2 90.12 Stress 2 88.48 Hypotension 4 87.04 Headache 1 85.68 Sprains And Strains 2 83.52 Hyperphagia 1 52.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It did not affect baseline plasma adrenocorticotropic hormone levels and renin activity, but decreased plasma corticosterone levels.

Neg (not) Regulation (affect) of Gene_expression (levels) of renin in plasma

1) Confidence 0.41 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392854 Disease Relevance 0.59 Pain Relevance 0.46

Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.

Regulation (Effects) of in blood Gene_expression (level) of renin in plasma

2) Confidence 0.40 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1906538 Disease Relevance 0.20 Pain Relevance 0.05

The morphological characteristics of the hamartomatous abnormality are described and evidences are put forward which would suggest that the liver lesion might have been the site of the abnormal renin production which was responsible for the systemic arterial hypertension.

Regulation (responsible) of Gene_expression (production) of renin in liver associated with pressure and volume under development

3) Confidence 0.27 Published 1975 Journal Virchows Arch A Pathol Anat Histol Section Abstract Doc Link 804756 Disease Relevance 0.60 Pain Relevance 0.09

General Comments

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