INT355217

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.21 Pain Relevance 0.04

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)

Anatomy Link Frequency brain 2 Ocln (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 15 73.56 anesthesia 3 44.72 ketamine 3 41.60 cva 3 40.56 Central nervous system 12 5.00 imagery 6 5.00 Intracerebroventricular 3 5.00 Multiple sclerosis 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 79.12 Brain Hemorrhage 6 73.56 Stroke 3 58.12 Hypoxia 9 45.40 Brain Injury 9 41.32 Cv General 4 Under Development 6 40.56 Cv Unclassified Under Development 6 37.84 Alzheimer's Dementia 9 37.20 Stress 6 15.28 Brain Tumor 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Given that the phosphorylation of the proteins is an immediate event and the disruption of the BBB also occurs shortly after sonication, it is plausible that the ultrasound-mediated diminished interaction of occludin and ZO-1 is due to alteration in phosphorylation level of tight junction proteins.

Negative_regulation (diminished) of occludin Binding (interaction) of

1) Confidence 0.27 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04

In the following study we show that the application of focused ultrasound in combination with ultrasound contrast agent disrupts the BBB integrity, and that this disruption is associated with reduced interaction of the tight junction protein occludin with ZO-1.

Negative_regulation (reduced) of occludin Binding (interaction) of

2) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.14 Pain Relevance 0

However, using immunoprecipitation analysis we show that the interaction of occludin and ZO-1 is reduced in the brain regions treated with ultrasound (Figure 3B).

Negative_regulation (reduced) of occludin Binding (interaction) of in brain

3) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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