INT355226

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.14

cytoplasm (VEGFA, Akt1) nucleoplasm (Akt1) transport (Akt1) aging (Akt1) extracellular space (VEGFA) growth (VEGFA)

Anatomy Link Frequency neuronal 1 VEGFA (Homo sapiens) Akt1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Intracerebroventricular 1 99.62 ischemia 5 97.56 Central nervous system 4 5.00 imagery 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 Multiple sclerosis 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Brain Hemorrhage 2 98.16 Targeted Disruption 1 97.58 Cv General 4 Under Development 2 78.12 Stress 2 35.12 Hypoxia 3 5.00 Alzheimer's Dementia 3 5.00 Brain Injury 3 5.00 Brain Tumor 2 5.00 Cv Unclassified Under Development 2 5.00 Osteoarthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transgenic animals expressing human VEGF165 under a neuron-specific promoter, as well as intracerebroventricular administration of VEGF both are shown to increase Akt activity and enhance neuronal survival after focal cerebral ischemia [23,44].

VEGF Positive_regulation (increase) of Akt in neuronal associated with brain hemorrhage, targeted disruption, ischemia and intracerebroventricular

1) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.14

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