INT35526

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 5.82
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eef1a2) GTPase activity (Eef1a2) cytoplasm (Eef1a2)
Anatomy Link Frequency
muscle 2
Chest 1
Eef1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
cINOD 8 98.28 Very High Very High Very High
Pain 2 98.04 Very High Very High Very High
Potency 11 97.80 Very High Very High Very High
headache 2 93.12 High High
corticosteroid 6 88.56 High High
Inflammation 59 74.56 Quite High
Neuropeptide 5 70.08 Quite High
Opioid 5 67.56 Quite High
Enkephalin 5 66.48 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 12 100.00 Very High Very High Very High
Injury 2 100.00 Very High Very High Very High
Toxicity 2 99.72 Very High Very High Very High
Pulmonary Disease 41 99.36 Very High Very High Very High
Calcification 139 99.28 Very High Very High Very High
Heart Arrhythmia 287 99.04 Very High Very High Very High
Influenza Virus Infection 2 98.82 Very High Very High Very High
Myalgia 2 98.04 Very High Very High Very High
INFLAMMATION 82 97.72 Very High Very High Very High
Rhabdomyolysis 2 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the association between statin use and risk of prostate cancer among 69,047 eligible participants in the California Men's Health Study, a prospective cohort of Northern and Southern California Kaiser Permanente (KP) members, ages 45 to 69 years, initiated in 2002.
statin Spec (examined) Binding (association) of associated with reprotox - general 1
1) Confidence 0.34 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17971519 Disease Relevance 0.48 Pain Relevance 0
We have previously reported no association between statin use and prostate cancer in our hospital-based Case Control Surveillance Study.
statin Neg (no) Binding (association) of associated with reprotox - general 1
2) Confidence 0.31 Published 2010 Journal Pharmacoepidemiol Drug Saf Section Abstract Doc Link 20582910 Disease Relevance 0.45 Pain Relevance 0.36
Replacement of the 1-carboxy-3-phenylpropyl group by a carboxymethyl group decreased the inhibitory potency by more than 3 orders of magnitude, emphasizing the importance of the hydrophobic phenyl group for inhibitor binding to a hydrophobic pocket at the S1 subsite.
S1 Binding (binding) of associated with potency
3) Confidence 0.18 Published 1988 Journal Biochemistry Section Abstract Doc Link 3162384 Disease Relevance 0 Pain Relevance 0.26
The data indicate the presence of an extended binding site in the enzyme with residues interacting with S1, S1', and S3' subsites largely determining inhibitor binding.
S1 Binding (interacting) of
4) Confidence 0.18 Published 1988 Journal Biochemistry Section Abstract Doc Link 3162384 Disease Relevance 0 Pain Relevance 0.08
The data indicate the presence of an extended binding site in the enzyme with residues interacting with S1, S1', and S3' subsites largely determining inhibitor binding.
S1 Binding (interacting) of
5) Confidence 0.14 Published 1988 Journal Biochemistry Section Abstract Doc Link 3162384 Disease Relevance 0 Pain Relevance 0.08
The data indicate the presence of an extended binding site in the enzyme with residues interacting with S1, S1', and S3' subsites largely determining inhibitor binding.
S1 Binding (binding) of
6) Confidence 0.13 Published 1988 Journal Biochemistry Section Abstract Doc Link 3162384 Disease Relevance 0 Pain Relevance 0.08
Changes in the structure of the residue interacting with the S1' subsite could cause a more than 60-fold change in inhibition.
S1 Binding (interacting) of
7) Confidence 0.11 Published 1988 Journal Biochemistry Section Abstract Doc Link 3162384 Disease Relevance 0 Pain Relevance 0.24
This review examines current evidence on statin interactions, mechanism of injury and toxicity.
statin Binding (interactions) of associated with toxicity and injury
8) Confidence 0.09 Published 2005 Journal Curr. Opin. Lipidol. Section Abstract Doc Link 16276242 Disease Relevance 0.65 Pain Relevance 0.09
CONCLUSION: As most individuals on statins are 'high-risk' patients, they tend to be on multiple agents for cardiovascular disease which may interact with their statin.
statin Binding (interact) of
9) Confidence 0.08 Published 2005 Journal Curr. Opin. Lipidol. Section Body Doc Link 16276242 Disease Relevance 0.12 Pain Relevance 0
In both instances, only reports with complaints of muscle pain or modification of creatine phospokinase (CPK) values and cases with one statin or one statin-fibrate association were selected.
statin Binding (association) of in muscle associated with pain and myalgia
10) Confidence 0.03 Published 2005 Journal Therapie Section Abstract Doc Link 16128275 Disease Relevance 0.17 Pain Relevance 0.10
In both instances, only reports with complaints of muscle pain or modification of creatine phospokinase (CPK) values and cases with one statin or one statin-fibrate association were selected.
statin Binding (association) of in muscle associated with pain and myalgia
11) Confidence 0.02 Published 2005 Journal Therapie Section Abstract Doc Link 16128275 Disease Relevance 0.17 Pain Relevance 0.10
Effect of a combination of CA and statin on in vitro VSMC calcification
statin Binding (combination) of associated with calcification and antagonist
12) Confidence 0.02 Published 2007 Journal Mol Cell Biochem Section Body Doc Link PMC2226060 Disease Relevance 1.37 Pain Relevance 0.05
Univariate, bivariate (Chi2, Fisher's Exact and Student's t-tests) and multivariate (stepwise linear regression) analyses were used to evaluate the association of statin use with mortality following CABG.


statin Binding (association) of
13) Confidence 0.02 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2841066 Disease Relevance 0.16 Pain Relevance 0
In a propensity matched analysis they demonstrated significant association between preoperative statin therapy and lower 30 day mortality and morbidity.
statin Binding (association) of
14) Confidence 0.01 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2841066 Disease Relevance 0.23 Pain Relevance 0
During the past few years, the association between statin use and development of AF has been examined in different clinical settings.
statin Binding (association) of associated with heart arrhythmia
15) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.93 Pain Relevance 0.13
Frost and colleagues published a paper in Chest [16], which described a cohort study and 2 small case-control studies (397 patients with influenza and 207 patients with COPD-related deaths) to examine the association of statin therapy with mortality.
statin Spec (examine) Binding (association) of in Chest associated with pulmonary disease and influenza virus infection
16) Confidence 0.00 Published 2009 Journal Respir Res Section Body Doc Link PMC2697974 Disease Relevance 1.08 Pain Relevance 0.04
To accommodate the disparate observations, we propose that all substrates
react in the same active site pocket, but that the unnatural esterase
substrates and GTN can occupy any of a number of poorly defined low-affinity
positions, whereas the dehydrogenase substrates can and must be bound to a
strictly defined high-affinity site to enable hydride transfer (supplementary
materials Scheme S1).
S1 Binding (bound) of
17) Confidence 0.00 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox