INT355273

Context Info Confidence 0.10 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency lungs 2 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 16 24.40 chemokine 10 15.92 cytokine 12 5.00 Pain 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Infection 110 94.52 Mycobacterial Infection 145 84.96 Granuloma 5 33.60 INFLAMMATION 16 24.40 Alzheimer's Dementia 5 5.00 Shock 4 5.00 Necrosis 3 5.00 Cancer 3 5.00 Sprains And Strains 2 5.00 Disease 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, depletion of Gr1+ neutrophils between D10–15 did not impact accumulation of total CD4+ T cells in the lungs (Figure 7a), but resulted in decreased accumulation of activated CD4+ cells (Figure 7b) and decreased percentage and number of IFN?

Negative_regulation (depletion) of Gene_expression (neutrophils) of Gr1 in lungs

1) Confidence 0.10 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.55 Pain Relevance 0

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