INT355569

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.17

cytosol (IRF6, NOS2) nucleus (IRF6, NOS2) cytoplasm (IRF6, NOS2) oxidoreductase activity (NOS2) intracellular (NOS2) DNA binding (IRF6)

IRF6 (Homo sapiens) NOS2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 18 84.72 Inflammation 21 84.32 corticosteroid 2 8.48 Arthritis 2 5.00 Inflammatory mediators 1 5.00 Analgesic 1 5.00 rheumatoid arthritis 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 22 84.32 Toxicity 1 71.44 Skin Diseases 4 60.16 Purpura 6 36.00 Disease 4 34.96 Increased Venous Pressure Under Development 3 5.00 Arthritis 2 5.00 Diabetes Mellitus 2 5.00 Hypertension 1 5.00 Impaired Glucose Tolerance 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot analyses revealed that the expression of COX-2 and iNOS was increased by LPS stimulation in HDMECs whereas the treatment with paeoniflorin resulted in a decrease in COX-2 and iNOS expression (Figure 3).

LPS Positive_regulation (increased) of Gene_expression (expression) of iNOS

1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

This test has worked.