INT355569

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, NOS2) nucleus (IRF6, NOS2) cytoplasm (IRF6, NOS2)
oxidoreductase activity (NOS2) intracellular (NOS2) DNA binding (IRF6)
IRF6 (Homo sapiens)
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 84.72 Quite High
Inflammation 21 84.32 Quite High
corticosteroid 2 8.48 Low Low
Arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 84.32 Quite High
Toxicity 1 71.44 Quite High
Skin Diseases 4 60.16 Quite High
Purpura 6 36.00 Quite Low
Disease 4 34.96 Quite Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analyses revealed that the expression of COX-2 and iNOS was increased by LPS stimulation in HDMECs whereas the treatment with paeoniflorin resulted in a decrease in COX-2 and iNOS expression (Figure 3).


LPS Positive_regulation (increased) of Gene_expression (expression) of iNOS
1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

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