INT355656

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0.13

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Anatomy Link Frequency brainstem 2 Cybb (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 7 96.16 gABA 14 82.88 Glutamate 9 5.00 ketamine 3 5.00 Bioavailability 2 5.00 Neuronal excitability 2 5.00 antagonist 2 5.00 Spinal cord 1 5.00 depression 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Chronic Renal Failure 37 99.64 Pressure And Volume Under Development 14 98.68 Renal Disease 1 88.76 Stress 11 71.76 Hypertension 6 5.00 Overdose 1 5.00 Bites And Stings 1 5.00 Decapitation 1 5.00 Depression 1 5.00 Urological Neuroanatomy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C).

Positive_regulation (increase) of Transcription (abundance) of gp91phox in brainstem associated with medulla and chronic renal failure

1) Confidence 0.01 Published 2010 Journal International Journal of Hypertension Section Abstract Doc Link PMC3022169 Disease Relevance 1.13 Pain Relevance 0.13

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