INT355721

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.03
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Hist2h4) biological_process (Hist2h4)
Anatomy Link Frequency
hippocampus 1
Hist2h4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 60 94.40 High High
ischemia 3 8.44 Low Low
long-term potentiation 9 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 72 99.00 Very High Very High Very High
Stress 192 98.08 Very High Very High Very High
Status Epilepticus 3 95.36 Very High Very High Very High
Convulsion 12 92.80 High High
Post-traumatic Stress Disorder 27 70.40 Quite High
Coma 3 9.36 Low Low
Cv Unclassified Under Development 3 8.44 Low Low
Mental Disorders 12 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Positive_regulation (increase) of H4 in hippocampus associated with convulsion, status epilepticus and hippocampus
1) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.57 Pain Relevance 0.15
The results of the fear conditioning study showed that footshock stress significantly increased the levels of total, exon I, and exon IV BDNF mRNA, with significantly increased acetylation levels of both histone H3 and H4, at the promoter of exons I and IV, followed by enhanced freezing to fear-context exposure.
Positive_regulation (increased) of H4 associated with stress and anxiety disorder
2) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.73 Pain Relevance 0.08
Although it remains unknown whether histone H3 and H4 acetylation play different roles in fear consolidation, the fact that SPS increased acetylation of H3 as well as H4 at the BDNF promoters of exons I and IV after FC, indicates that coordinate enhancement of histone acetylation may play a role in the marked enhancement of contextual fear memory in SPS rats.
Positive_regulation (acetylation) of H4 associated with stress and anxiety disorder
3) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.73 Pain Relevance 0.06

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