INT355815

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.72

cell differentiation (NAV1) endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1) endoplasmic reticulum (BACE1) enzyme binding (BACE1)

Anatomy Link Frequency neuronal 2 BACE1 (Homo sapiens) NAV1 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 99 100.00 Nav1.1 4 92.80 imagery 2 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 95.00 Neuroblastoma 3 90.00 Adhesions 1 74.48 Disease 4 25.48 Alzheimer's Dementia 4 21.32 Stress 3 5.00 Cv Unclassified Under Development 1 5.00 Injury 1 5.00 Disease Progression 1 5.00 Brain Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data strongly suggest that BACE1 can regulate neuronal function, possibly by cleaving Nav?

BACE1 Regulation (regulate) of Positive_regulation (cleaving) of Nav in neuronal associated with sodium channel

1) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.26 Pain Relevance 0.72

General Comments

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