INT356286

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.50

signal transduction (Ngf, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1) aging (Ngf) microtubule organizing center (Mapk1) extracellular space (Ngf)

Ngf (Rattus norvegicus) Mapk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 13 100.00 nociceptor 11 94.16 Hyperalgesia 14 89.12 Inflammation 3 88.60 withdrawal 6 5.00 agonist 4 5.00 Kinase C 2 5.00 Analgesic 1 5.00 Nerve growth factor 1 5.00 sodium channel 1 5.00

Disease Link Frequency Relevance Heat Pain 13 100.00 Hyperalgesia 14 89.12 INFLAMMATION 3 88.60 Wound Healing 3 87.12 Injury 2 81.76 Hypersensitivity 1 76.76 Nociception 22 45.52 Starvation 2 5.00 Cancer 2 5.00 Poisoning 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Accordingly, GDNF and NGF-induced mechanical pain sensitization has been identified to depend on the activation of Erk1/2 [19,22].

NGF Regulation (depend) of Positive_regulation (activation) of Erk1/2 associated with pain

1) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.76 Pain Relevance 0.50

General Comments

This test has worked.