INT356287

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.30

signal transduction (Ngf, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1) aging (Ngf) microtubule organizing center (Mapk1) extracellular space (Ngf)

Ngf (Rattus norvegicus) Mapk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat nociceptor 11 84.00 Pain 13 75.00 Hyperalgesia 14 25.00 withdrawal 6 5.00 agonist 4 5.00 Inflammation 3 5.00 Kinase C 2 5.00 Analgesic 1 5.00 Nerve growth factor 1 5.00 sodium channel 1 5.00

Disease Link Frequency Relevance Heat Nociception 22 90.72 Pain 13 75.00 Hyperalgesia 14 25.00 Wound Healing 3 5.00 INFLAMMATION 3 5.00 Starvation 2 5.00 Cancer 2 5.00 Injury 2 5.00 Poisoning 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The growth factors NGF, GDNF and EGF activate the MAP-kinase Erk1/2 via receptor tyrosine kinase signalling.

NGF Positive_regulation (activate) of Erk1/2

1) Confidence 0.05 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3023724 Disease Relevance 0.17 Pain Relevance 0.30

General Comments

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