INT35928

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 17
Disease Relevance 12.23
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
molecular_function (Baat) lipid metabolic process (Baat)
Anatomy Link Frequency
BAT 12
neurons 2
spinal 1
heart 1
Body 1
Baat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 35 99.76 Very High Very High Very High
Intracerebroventricular 28 99.66 Very High Very High Very High
qutenza 9 99.62 Very High Very High Very High
Rostral ventrolateral medulla 15 99.54 Very High Very High Very High
opiate 7 99.20 Very High Very High Very High
mu opioid receptor 10 96.32 Very High Very High Very High
Raphe magnus 6 90.44 High High
Morphine 3 89.64 High High
narcan 5 89.52 High High
antagonist 5 89.16 High High
Disease Link Frequency Relevance Heat
Obesity 187 100.00 Very High Very High Very High
Fever 14 97.76 Very High Very High Very High
Ganglion Cysts 1 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noxious stimulation suppressed BAT activation, suggesting that cells inhibited by noxious stimulation facilitate spinal circuits controlling BAT.
Positive_regulation (activation) of BAT in spinal associated with obesity
1) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 1.04 Pain Relevance 0.45
Yet it is unclear which medullary raphe cells participate in cold defense and how participating cells contribute to BAT activation.
Positive_regulation (activation) of BAT in BAT associated with obesity and raphe
2) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 0.57 Pain Relevance 0.22
Therefore, the administration of capsaicin or isothiocyanate activates BAT function in rats.
Positive_regulation (activates) of BAT in BAT associated with qutenza and obesity
3) Confidence 0.61 Published 1988 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 3244046 Disease Relevance 0.76 Pain Relevance 0.33
Thus, both p5HT and non-p5HT OFF cells in the medullary raphe facilitate BAT activation in response to cold challenge or pyrogen.
Positive_regulation (activation) of BAT in BAT associated with obesity and raphe
4) Confidence 0.60 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 0.79 Pain Relevance 0.38
To test for modulation of BAT activation by non-p5HT cells that are either excited (ON cells) or inhibited (OFF cells) by noxious cutaneous stimulation, noxious stimuli were applied during evoked BAT temperature increases.
Positive_regulation (activation) of BAT in BAT associated with obesity
5) Confidence 0.43 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 0.97 Pain Relevance 0.38
RESULTS: In series 1, anesthesia or exposure to cold increased (18)F-FDG uptake in BAT to levels 14-fold and 4.9-fold, respectively, greater than the control nonstimulated values.
Positive_regulation (increased) of BAT in BAT
6) Confidence 0.41 Published 2004 Journal J. Nucl. Med. Section Body Doc Link 15235065 Disease Relevance 0.07 Pain Relevance 0
However, none of the 147 physiologically identified non-serotonergic (non-p5HT) cells recorded responded to thermoregulatory challenges that evoked an increase in BAT temperature.
Positive_regulation (increase) of BAT in BAT associated with obesity
7) Confidence 0.40 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 0.96 Pain Relevance 0.37
Therefore, we recorded extracellularly from raphe cells during three thermoregulatory challenges that evoked an increase in BAT temperature in anesthetized rats: central cold, ambient cold, or intracerebroventricular prostaglandin E2 (PGE2) injection.
Positive_regulation (increase) of BAT in BAT associated with obesity, intracerebroventricular and raphe
8) Confidence 0.40 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 0.65 Pain Relevance 0.22
The present study was conducted to determine if FEN-induced activation of BAT is affected by the ambient temperature at which animals are maintained.
Positive_regulation (activation) of BAT in BAT associated with obesity
9) Confidence 0.37 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151039 Disease Relevance 0.63 Pain Relevance 0
Activation of neurons in the rostral RPa and RVLM are essential for the increases in BAT thermogenesis and renal sympathoexcitation, respectively, induced by activation of central mu-opioid receptors.
Positive_regulation (increases) of BAT in neurons associated with rostral ventrolateral medulla, obesity and mu opioid receptor
10) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.86 Pain Relevance 0.52
Increases in brown adipose tissue (BAT) sympathetic nerve activity (SNA) (peak, +326% of control), BAT temperature (peak, +0.8 degrees C), renal SNA (peak, +146% of control), and heart rate (HR; peak, +32 beats/min) produced by intravenous fentanyl were abolished by premamillary transection of the neuraxis but were mimicked by intracerebroventricular administration of fentanyl, which also increased arterial pressure (AP; peak, +12 mmHg).
Positive_regulation (Increases) of BAT in heart associated with obesity and intracerebroventricular
11) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.45 Pain Relevance 0.25
Microinjection of glycine (0.5 M, 60 nl) to inhibit local neurons in the rostral raphe pallidus (RPa) selectively reversed the intracerebroventricular fentanyl-evoked increases in BAT SNA and HR, while the fentanyl-evoked excitation in RSNA, the pressor responses, and the tachycardic responses were reversed by inhibition of neurons in the rostral ventrolateral medulla (RVLM).
Positive_regulation (increases) of BAT in neurons associated with rostral ventrolateral medulla, obesity, intracerebroventricular and raphe
12) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.73 Pain Relevance 0.56
Prior inhibition of neurons in the dorsomedial hypothalamus eliminated the intracerebroventricular fentanyl-evoked increases in BAT SNA, BAT temperature, and HR, but not those in RSNA or AP.
Positive_regulation (increases) of BAT in BAT associated with obesity and intracerebroventricular
13) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.98 Pain Relevance 0.57
Prior inhibition of neurons in the dorsomedial hypothalamus eliminated the intracerebroventricular fentanyl-evoked increases in BAT SNA, BAT temperature, and HR, but not those in RSNA or AP.
Positive_regulation (increases) of BAT in BAT associated with obesity and intracerebroventricular
14) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.97 Pain Relevance 0.57
Body temperature was determined in conscious male Sprague-Dawley rats using implanted temperature transmitters, and sympathetic activation of BAT was determined by measuring norepinephrine (NE) content.
Positive_regulation (activation) of BAT in Body associated with obesity
15) Confidence 0.34 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151039 Disease Relevance 0.74 Pain Relevance 0
The results indicate clearly that the hyperthermia occurring in unrestrained rats after acute central or peripheral opiate administration is not due to selective activation of BAT thermogenesis.
Positive_regulation (activation) of BAT in BAT associated with obesity, opiate and fever
16) Confidence 0.34 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6491989 Disease Relevance 0.59 Pain Relevance 0.29
Since BAT is activated by cold and feeding via sympathetic nervous system, the small spikes seemed to be exhibited by sympathetic fibers.
Positive_regulation (activated) of BAT in BAT associated with obesity
17) Confidence 0.33 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 15893704 Disease Relevance 0.48 Pain Relevance 0.31

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