INT36052

Context Info Confidence 0.28 First Reported 1988 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 4.72 Pain Relevance 2.32

signal transduction (IL2RG) plasma membrane (IL2RG)

Anatomy Link Frequency lymphocytes 2 bowel 2 mononuclear cells 2 IL2RG (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 16 99.90 anesthesia 12 99.76 Inflammation 7 98.88 rheumatoid arthritis 5 97.56 abdominal pain 4 91.88 isoflurane 2 91.84 cytokine 8 77.76 methotrexate 1 56.48 Pain 3 25.00

Disease Link Frequency Relevance Heat Necrosis 2 100.00 Cancer 2 100.00 Disease 32 99.90 Inflammatory Bowel Disease 12 98.88 Systemic Lupus Erythematosus 2 98.76 Rheumatoid Arthritis 6 97.56 Bacterial Endocarditis 1 96.52 Crystal Associated Disease 1 94.32 Abdominal Pain 4 91.88 INFLAMMATION 5 90.28

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Anatomy

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Speculation

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Disease term

Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout.

Positive_regulation (elevated) of Gene_expression (Levels) of IL-2R associated with bacterial endocarditis, rheumatoid arthritis, crystal associated disease and systemic lupus erythematosus

1) Confidence 0.28 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 0.76 Pain Relevance 0.09

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (soluble) of Gene_expression (synthesis) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer

2) Confidence 0.28 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.36 Pain Relevance 0.52

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (increase) of Gene_expression (synthesis) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer

3) Confidence 0.28 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53

This agent is an interleukin-2 receptor (IL-2R)-targeted cytotoxin which kills activated IL-2R-expressing lymphocytes at 10(-10) M concentrations.

Positive_regulation (activated) of Gene_expression (expressing) of IL-2R in lymphocytes

4) Confidence 0.07 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324945 Disease Relevance 0.37 Pain Relevance 0.14

Patients with moderate/severe Crohn's disease had elevated mean serum levels of IL-6 and IL-2R when compared with those with mild and inactive disease (p < 0.05); however, neither marker distinguished between inactive and mild disease.

Positive_regulation (elevated) of Gene_expression (levels) of IL-2R associated with crohn's disease and disease

5) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.80 Pain Relevance 0.60

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Positive_regulation (elevated) of Gene_expression (levels) of IL-2R in bowel associated with inflammatory bowel disease and inflammation

6) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.26

By searching for the effects of CPB and anesthesia, interleukin-2 receptor (IL-2R) expression upon the surface of peripheral blood mononuclear cells (PBMC), as well as interleukin-2 (IL-2) production in vitro was traced 55 min after anesthesia, at end of CPB, on postoperative 1, 7, and 14 day versus preanesthesia control.

Positive_regulation (traced) of Gene_expression (expression) of IL-2R in mononuclear cells associated with anesthesia

7) Confidence 0.02 Published 1997 Journal Chin. Med. Sci. J. Section Abstract Doc Link 11360554 Disease Relevance 0 Pain Relevance 0.20

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