INT36052

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Context Info
Confidence 0.28
First Reported 1988
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.72
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL2RG) plasma membrane (IL2RG)
Anatomy Link Frequency
lymphocytes 2
bowel 2
mononuclear cells 2
IL2RG (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 16 99.90 Very High Very High Very High
anesthesia 12 99.76 Very High Very High Very High
Inflammation 7 98.88 Very High Very High Very High
rheumatoid arthritis 5 97.56 Very High Very High Very High
abdominal pain 4 91.88 High High
isoflurane 2 91.84 High High
cytokine 8 77.76 Quite High
methotrexate 1 56.48 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Disease 32 99.90 Very High Very High Very High
Inflammatory Bowel Disease 12 98.88 Very High Very High Very High
Systemic Lupus Erythematosus 2 98.76 Very High Very High Very High
Rheumatoid Arthritis 6 97.56 Very High Very High Very High
Bacterial Endocarditis 1 96.52 Very High Very High Very High
Crystal Associated Disease 1 94.32 High High
Abdominal Pain 4 91.88 High High
INFLAMMATION 5 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout.
Positive_regulation (elevated) of Gene_expression (Levels) of IL-2R associated with bacterial endocarditis, rheumatoid arthritis, crystal associated disease and systemic lupus erythematosus
1) Confidence 0.28 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 0.76 Pain Relevance 0.09
We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.
Positive_regulation (soluble) of Gene_expression (synthesis) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer
2) Confidence 0.28 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.36 Pain Relevance 0.52
We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.
Positive_regulation (increase) of Gene_expression (synthesis) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer
3) Confidence 0.28 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53
This agent is an interleukin-2 receptor (IL-2R)-targeted cytotoxin which kills activated IL-2R-expressing lymphocytes at 10(-10) M concentrations.
Positive_regulation (activated) of Gene_expression (expressing) of IL-2R in lymphocytes
4) Confidence 0.07 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324945 Disease Relevance 0.37 Pain Relevance 0.14
Patients with moderate/severe Crohn's disease had elevated mean serum levels of IL-6 and IL-2R when compared with those with mild and inactive disease (p < 0.05); however, neither marker distinguished between inactive and mild disease.
Positive_regulation (elevated) of Gene_expression (levels) of IL-2R associated with crohn's disease and disease
5) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.80 Pain Relevance 0.60
Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).
Positive_regulation (elevated) of Gene_expression (levels) of IL-2R in bowel associated with inflammatory bowel disease and inflammation
6) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.26
By searching for the effects of CPB and anesthesia, interleukin-2 receptor (IL-2R) expression upon the surface of peripheral blood mononuclear cells (PBMC), as well as interleukin-2 (IL-2) production in vitro was traced 55 min after anesthesia, at end of CPB, on postoperative 1, 7, and 14 day versus preanesthesia control.
Positive_regulation (traced) of Gene_expression (expression) of IL-2R in mononuclear cells associated with anesthesia
7) Confidence 0.02 Published 1997 Journal Chin. Med. Sci. J. Section Abstract Doc Link 11360554 Disease Relevance 0 Pain Relevance 0.20

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