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Context Info
Confidence 0.72
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 32.64
Pain Relevance 17.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
spleen 4
alveolar macrophages 2
cerebellum 2
cortex 2
brain stem 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 351 100.00 Very High Very High Very High
cytokine 267 100.00 Very High Very High Very High
metalloproteinase 23 100.00 Very High Very High Very High
chemokine 6 100.00 Very High Very High Very High
cINOD 24 99.92 Very High Very High Very High
spastic colon 10 99.92 Very High Very High Very High
IPN 33 99.84 Very High Very High Very High
peptic ulcer disease 2 99.76 Very High Very High Very High
Neuritis 33 99.62 Very High Very High Very High
Inflammatory mediators 24 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 435 100.00 Very High Very High Very High
Cancer 70 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Neointima 1 100.00 Very High Very High Very High
Adhesions 20 99.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 99.92 Very High Very High Very High
Disease 127 99.76 Very High Very High Very High
Experimental Autoimmune Neuritis 33 99.62 Very High Very High Very High
Anaplastic Astrocytoma 5 99.60 Very High Very High Very High
Ulcers 6 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that differences in transcription of the IL1-beta gene exist between these 2 cell types.
Transcription (transcription) of IL1-beta
1) Confidence 0.72 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.40 Pain Relevance 0.13
Recently, Kimura et al. [11] employed allele-specific transcript quantification to examine the effects of IL1B -31C>T and 3953C>T polymorphisms on the level of IL-1B transcription.
Transcription (transcription) of IL-1B
2) Confidence 0.72 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.47 Pain Relevance 0.03
The mRNA levels of IL-1alpha, IL-1beta, IL-6, IL-8, and IL-18 were measured concomitantly by quantitative real-time RT-PCR.
Transcription (levels) of IL-1beta
3) Confidence 0.69 Published 2003 Journal Cytokine Section Abstract Doc Link 12849707 Disease Relevance 0.25 Pain Relevance 0.37
The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone.
Transcription (levels) of IL-1beta
4) Confidence 0.69 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.34 Pain Relevance 0.25
We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone.
Transcription (expressions) of IL-1beta in osteoblasts
5) Confidence 0.67 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.30
The hormone also attenuated TNF-alpha-dependent mRNA expression of IL-1beta.
Transcription (expression) of IL-1beta
6) Confidence 0.67 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.39 Pain Relevance 0.24
Among the NSAIDs tested, mofezolac and sodium diclofenac were found to stimulate the mRNA expression for IL-1ra without affecting the mRNA expression for IL-1 beta.
Transcription (expression) of IL-1 associated with cinod and diclofenac
7) Confidence 0.65 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.22 Pain Relevance 0.74
Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.
Transcription (expression) of IL-1 in PBMC
8) Confidence 0.65 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.24 Pain Relevance 0.76
Comparing normal alveolar macrophages to those from patients with sarcoidosis showed no differences in the kinetics of IL1-beta mRNA expression or in the LPS-induced levels of IL1-beta mRNA accumulation.
Transcription (expression) of IL1-beta in alveolar macrophages associated with sarcoidosis
9) Confidence 0.53 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.67 Pain Relevance 0.10
In addition, augmented levels of IL1-beta transcript were not noted in unstimulated sarcoid alveolar macrophages.
Transcription (levels) of IL1-beta in alveolar macrophages associated with sarcoidosis
10) Confidence 0.53 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.74 Pain Relevance 0.10
If the increased expression of IL-1B observed in brain of cerebral malaria patients [2,3] is due to the increased transcription of IL1B caused by the IL1B -31T allele [11], the frequency of IL1B -31T should be higher in cerebral malaria patients than in mild malaria patients.
Transcription (transcription) of IL1B in brain associated with malaria and cerebral malaria
11) Confidence 0.53 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.83 Pain Relevance 0
Furthermore, expression of IL1B mRNA was detected in the spleen, cortex, cerebellum, and brain stem of most pediatric patients that died of cerebral malaria, but it was not detected in those of uninfected individuals [3].
Transcription (detected) of IL1B in cortex associated with cerebral malaria
12) Confidence 0.53 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.51 Pain Relevance 0.11
Furthermore, expression of IL1B mRNA was detected in the spleen, cortex, cerebellum, and brain stem of most pediatric patients that died of cerebral malaria, but it was not detected in those of uninfected individuals [3].
Transcription (expression) of IL1B in cortex associated with cerebral malaria
13) Confidence 0.53 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.51 Pain Relevance 0.11
Interleukin-1beta mRNA levels are increased in the mucosa of those who develop PI-IBS, who also show increased gut permeability.
Transcription (levels) of Interleukin-1beta in gut associated with spastic colon
14) Confidence 0.52 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17238025 Disease Relevance 0.91 Pain Relevance 0.92
In addition, the levels of TNF-alpha, IL-6, and IL-1beta mRNA expression in FLS cells induced by a TNF-alpha and IL-1beta co-treatment were largely inhibited by a KTBE treatment.
Transcription (expression) of IL-1beta
15) Confidence 0.52 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 19023550 Disease Relevance 0.26 Pain Relevance 0.29
IL-1beta and MCP-1 mRNAs were nearly undetectable.
Transcription (undetectable) of IL-1beta
16) Confidence 0.52 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12775581 Disease Relevance 1.16 Pain Relevance 1.20
RESULTS: Leu-ENK, met-ENK, and END inhibited tumor necrosis factor-alpha and interleukin 1beta production at the level of mRNA expression.
Transcription (expression) of interleukin 1beta
17) Confidence 0.52 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669152 Disease Relevance 0.15 Pain Relevance 0
Furthermore, CTS actions appear to involve disruption/regulation of signal transduction cascade of rHuIL-1beta upstream of mRNA transcription.


Transcription (transcription) of IL-1beta
18) Confidence 0.52 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
Before treatment a significant positive relation was observed between the amount of IL-1beta mRNA in gastric fundic gland mucosa and gastric juice pH.
Transcription (amount) of IL-1beta in gastric juice
19) Confidence 0.52 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.54 Pain Relevance 0.09
The amount of IL-1beta mRNA in gastric fundic gland mucosa was also measured by a competitive reverse transcription-polymerase chain reaction method.
Transcription (amount) of IL-1beta in gland
20) Confidence 0.52 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.54 Pain Relevance 0.10

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