INT3645

From wiki-pain
Revision as of 04:09, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.64
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) oxidoreductase activity (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
liver 6
body 2
bands 1
heart 1
Grhpr (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 7 99.88 Very High Very High Very High
methadone 28 99.72 Very High Very High Very High
Morphine 16 99.64 Very High Very High Very High
tolerance 5 97.04 Very High Very High Very High
Paracetamol 30 94.16 High High
Analgesic 4 92.36 High High
Antinociceptive 4 91.96 High High
analgesia 2 86.40 High High
antagonist 3 84.76 Quite High
Calcium channel 1 63.92 Quite High
Disease Link Frequency Relevance Heat
Stress 92 100.00 Very High Very High Very High
Body Weight 23 99.70 Very High Very High Very High
Hepatotoxicity 8 98.60 Very High Very High Very High
Toxicity 9 96.56 Very High Very High Very High
Sprains And Strains 2 78.72 Quite High
Hypoglycemia 2 75.28 Quite High
Lung Cancer 2 75.00 Quite High
Nociception 1 72.16 Quite High
Overdose 1 71.92 Quite High
Congenital Anomalies 4 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of morphine up to 100 mg/kg to male mice increased the specific activity of microsomal c reductase by about 70%.
Positive_regulation (increased) of reductase associated with morphine
1) Confidence 0.42 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 826227 Disease Relevance 0 Pain Relevance 0.68
Three hr after i.p. administration of a single dose of 30 mg/kg of morphine to male mice, an increase in specific activity of NADPH-cytochrome c reductase by about 10% and the content of cytochrome P-450 by about 14% of their liver microsomes was observed.Administration of 30 mg/kg of morphine, once daily,during 5 days, caused about 16% and 9% increases in specific activity of c reductase and the content of P-450 respectively.
Positive_regulation (increase) of reductase in liver associated with morphine
2) Confidence 0.31 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 826227 Disease Relevance 0 Pain Relevance 0.46
activation (e.g., in the fasted state) is crucial in inducing transcriptional activation of Grhpr, thereby favouring a conversion of hydroxypyruvate to D-glycerate, a substrate needed in glucose synthesis [80].
Positive_regulation (activation) of Grhpr
3) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.08 Pain Relevance 0.03
Chronic administration of progressively increasing doses of methadone (up to 40 mg/kg body weight) to male mice increased the specific activity of c reductase.
Positive_regulation (increased) of reductase in body associated with body weight and methadone
4) Confidence 0.29 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 821409 Disease Relevance 0.27 Pain Relevance 0.60
Administration of a single acute dose (20 mg/kg body weight) of methadone hydrochloride to both male and female mice increased the specific activity of NADPH-cytochrome c reductase and did not change much the content of cytochrome P-450 of their liver microsomes.
Neg (not) Positive_regulation (increased) of reductase in liver associated with body weight and methadone
5) Confidence 0.29 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 821409 Disease Relevance 0.23 Pain Relevance 0.45
Administration of multiple acute doses of methadone in male mice increased the specific activity of cytochrome c reductase and the content of cytochrome P-450 of their liver microsomes.
Positive_regulation (increased) of reductase in liver associated with methadone
6) Confidence 0.21 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 821409 Disease Relevance 0.25 Pain Relevance 0.56
It was established that 1 h after nifedipine (50 mg/kg) treatment, cytochrome P450 content, NADPH cytochrome c reductase and ethylmorphine-N-demethylase (EMND) activities were increased in the liver microsomes.
Positive_regulation (increased) of reductase in liver
7) Confidence 0.06 Published 2000 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 11346895 Disease Relevance 0.07 Pain Relevance 0.80
Repeated administration of rifampicin (50 mg/kg i.p. daily for 6 days) shortened hexobarbital sleeping time and increased liver weight, microsomal cytochrome P-450 and heme contents, NADPH-cytochrome c reductase and ethylmorphine-N-demethylase activities.
Positive_regulation (increased) of reductase in liver
8) Confidence 0.05 Published 1994 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 7737232 Disease Relevance 0.17 Pain Relevance 0.74
The activities of the enzymes NADPH cytochrome c reductase and NADPH oxidase were both elevated significantly by day 2 of administration.
Positive_regulation (elevated) of reductase
9) Confidence 0.04 Published 1980 Journal Drug Alcohol Depend Section Abstract Doc Link 6768537 Disease Relevance 0 Pain Relevance 0.68
NF (50 mg/kg) increased cytochrome P-450 content, NADPH-cytochrome c reductase and ethylmorphine-N-demethylase activities.
Positive_regulation (increased) of reductase
10) Confidence 0.03 Published 1995 Journal Arch. Toxicol. Section Abstract Doc Link 8773183 Disease Relevance 0.39 Pain Relevance 0.62
Oral gavage administration of benzo(a)pyrene (50 mg/kg body weight) to mice led to a marked increase in oxidative stress indicated by alterations in pulmonary lipid peroxidation, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase) and non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E and vitamin A).
Positive_regulation (increase) of reductase in body associated with stress and body weight
11) Confidence 0.02 Published 2008 Journal Phytother Res Section Abstract Doc Link 18338764 Disease Relevance 0.45 Pain Relevance 0.33
Cytochrome b5 reductase level was slightly increased when
the immunoreactive bands were quantified by densitometry
(Fig. 1C). 
Positive_regulation (increased) of reductase in bands
12) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0
Furthermore, oral administration of CoQ10 increased also NADPH-CoQ reductase activity, which was decreased by statin administration (Fig. 2).
Positive_regulation (increased) of reductase
13) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.11 Pain Relevance 0
Furthermore, we observed that prolonged supplementation with CoQ10 caused a significant increase in the NADPH-CoQ reductase activity, and protected partially hepatotoxicity induced by carbon tetrachloride and H2O2.
Positive_regulation (increase) of reductase associated with hepatotoxicity
14) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.55 Pain Relevance 0
CoQ10 administration increased NADPH-CoQ reductase activity in the liver and heart, and the NADPH-CoQ reductase activity in the simvastatin and CoQ10-cotreated group was higher than that of the simvastatin group.


Positive_regulation (increased) of reductase in heart
15) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.37 Pain Relevance 0
Histidine and DTPA, the metal chelator; BHA and low concentration of capsaicin, the inducer of NADH-quinone reductase, effectively protected Cs(a) and Cs(b) against lawsone in this study.
Positive_regulation (inducer) of reductase associated with qutenza
16) Confidence 0.00 Published 2007 Journal Toxicology Section Abstract Doc Link 17442476 Disease Relevance 0.32 Pain Relevance 0.10
CoQ10 administration increased NADPH-CoQ reductase activity in the liver and heart, and the NADPH-CoQ reductase activity in the simvastatin and CoQ10-cotreated group was higher than that of the simvastatin group.


Positive_regulation (increased) of reductase in liver
17) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox