INT37080

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Context Info
Confidence 0.05
First Reported 1981
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (OAS2) mitochondrion (OAS2) endoplasmic reticulum (OAS2)
RNA binding (OAS2) nucleus (OAS2) nucleotidyltransferase activity (OAS2)
OAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 99.38 Very High Very High Very High
cytokine 5 88.96 High High
Spinal cord 4 75.00 Quite High
ischemia 3 75.00 Quite High
Angina 1 70.96 Quite High
anesthesia 1 58.56 Quite High
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Atherosclerosis 3 99.46 Very High Very High Very High
Premature Birth 1 97.36 Very High Very High Very High
INFLAMMATION 4 95.20 Very High Very High Very High
Adverse Drug Reaction 2 93.84 High High
Cancer 1 77.60 Quite High
Necrosis 1 77.04 Quite High
Arteriosclerosis Obliterans 1 76.96 Quite High
Spinal Cord Ischemia 1 75.00 Quite High
Increased Venous Pressure Under Development 1 75.00 Quite High
Cv Unclassified Under Development 2 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rofecoxib is a novel NSAID which selectively inhibits prostaglandin endoperoxide H synthase-2 and has no effect on prostaglandin endoperoxide H synthase-1.
Negative_regulation (inhibits) of synthase-2 associated with cinod
1) Confidence 0.05 Published 2002 Journal Ann. Allergy Asthma Immunol. Section Abstract Doc Link 11926629 Disease Relevance 0.34 Pain Relevance 0.37
We hypothesize that prostacyclin (PGI2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial PGI2 synthetase is inhibited by lipid peroxides.
Negative_regulation (inhibited) of PGI2 synthetase associated with atherosclerosis
2) Confidence 0.01 Published 1981 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 6117899 Disease Relevance 0.43 Pain Relevance 0.07
Prostaglandin H synthase-2 (PGHS-II) specific inhibitors have been proposed as a potential treatment in the prevention of preterm birth.
Negative_regulation (inhibitors) of synthase-2 associated with premature birth
3) Confidence 0.00 Published 2002 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12144874 Disease Relevance 0.38 Pain Relevance 0.21
PGI2 synthetase activity decreased by 40% at 30 min, with return to normal at later time points.
Negative_regulation (decreased) of PGI2 synthetase
4) Confidence 0.00 Published 1987 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3476967 Disease Relevance 0.15 Pain Relevance 0.24

General Comments

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