INT37110

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.38
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptgfr) plasma membrane (Ptgfr) cytoplasm (Ptgfr)
signal transducer activity (Ptgfr)
Anatomy Link Frequency
outflow 1
myometrium 1
plasma 1
uterus 1
brain 1
Ptgfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 4 99.96 Very High Very High Very High
agonist 15 99.68 Very High Very High Very High
bradykinin 16 99.56 Very High Very High Very High
lidocaine 3 98.98 Very High Very High Very High
Serotonin 10 97.68 Very High Very High Very High
Dismenorea 2 96.52 Very High Very High Very High
Dopamine 1 95.12 Very High Very High Very High
algogenic 1 94.36 High High
Glutamate 14 93.36 High High
aspirin 3 92.00 High High
Disease Link Frequency Relevance Heat
Hypothermia 6 99.10 Very High Very High Very High
Ocular Hypertension 90 98.68 Very High Very High Very High
Diuresis 3 96.88 Very High Very High Very High
Dysmenorrhea 2 96.52 Very High Very High Very High
Cv Unclassified Under Development 7 91.00 High High
Glaucoma 80 79.04 Quite High
Pain 2 78.96 Quite High
Paralysis 1 75.68 Quite High
INFLAMMATION 5 58.72 Quite High
Conjunctivitis 3 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, acetylcholine, gamma-aminobutyric acid, histamine and purinergic receptor agonists did not affect PGF2 alpha accumulation in this preparation.
Positive_regulation (accumulation) of PGF2 alpha associated with agonist
1) Confidence 0.69 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.46
Moderate hypothermia (30 degrees C) attenuated the post-ischemic increase in the levels of PGF2 alpha.
Positive_regulation (increase) of PGF2 associated with hypothermia
2) Confidence 0.61 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953685 Disease Relevance 0.94 Pain Relevance 0.55
The plasma PGF2 alpha level and the rate of release of PGF2 alpha from isolated rat uterus increased progressively from day 18 to 20 of gestation.
Positive_regulation (increased) of PGF2 alpha in uterus
3) Confidence 0.44 Published 1987 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 3480546 Disease Relevance 0.06 Pain Relevance 0.18
The outputs of PGE2 and PGF2 alpha were also increased by caffeine.
Positive_regulation (increased) of PGF2
4) Confidence 0.41 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7708807 Disease Relevance 0 Pain Relevance 0.07
Lidocaine in therapeutic doses (2 mg/kg) will significantly increase 6-Keto PGF1 alpha in plasma as well as in aortic ring incubation chambers and in the effluent of isolated perfused lungs when compared to saline treated controls.
Positive_regulation (increase) of PGF1 in lungs associated with lidocaine
5) Confidence 0.40 Published 1980 Journal Prostaglandins Section Abstract Doc Link 6992240 Disease Relevance 0 Pain Relevance 0.26
In addition, most neurons responded vigorously to PGF2 alpha and BK, with responses to BK but not PGF2 alpha, reliably preceding the 'giant' uterine contractions that were also produced by these algogenic agents.
Positive_regulation (responded) of PGF2 in uterine associated with algogenic, dismenorea and bradykinin
6) Confidence 0.39 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348319 Disease Relevance 0.25 Pain Relevance 0.53
Renal venous plasma concentration of PGE2 increased significantly while the increase in PGF2 alpha was insignificant.
Positive_regulation (increase) of PGF2 in plasma
7) Confidence 0.18 Published 1981 Journal Acta Physiol. Scand. Section Abstract Doc Link 6797255 Disease Relevance 0.19 Pain Relevance 0
Bradykinin (5, 10 and 20 mg, ICV) increased the concentration of prostaglandin E2 (PGE2) but not of PGF2 alpha of rat brain.
Positive_regulation (increased) of PGF2 in brain associated with intracerebroventricular and bradykinin
8) Confidence 0.14 Published 1986 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 3797812 Disease Relevance 0 Pain Relevance 1.23
A longitudinal section of myometrium was removed, total RNA was extracted, and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for glyceraldehyde phosphate dehydrogenase (GAPDH), calponin, EP2, and FP receptor mRNA expression.
Positive_regulation (performed) of FP receptor mRNA in myometrium
9) Confidence 0.04 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0.07 Pain Relevance 0.07
Following absorption into the eye, the free acid form of travaprost interacts with the endogenous FP prostanoid receptor, to enhance aqueous humor outflow and lower intraocular pressure (IOP).
Positive_regulation (enhance) of FP prostanoid receptor in outflow associated with ocular hypertension
10) Confidence 0.03 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.86 Pain Relevance 0.09

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