INT37151

From wiki-pain
Revision as of 21:27, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 3.11
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 2
brain 2
substantia nigra 1
dopaminergic neurons 1
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 14 100.00 Very High Very High Very High
Substantia nigra 33 99.98 Very High Very High Very High
midbrain 61 99.56 Very High Very High Very High
Dopamine 1054 99.16 Very High Very High Very High
Locus ceruleus 21 96.12 Very High Very High Very High
Analgesic 5 93.44 High High
Potency 7 93.36 High High
Nucleus accumbens 81 89.64 High High
Ventral tegmentum 46 86.40 High High
monoamine 51 85.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 69 99.56 Very High Very High Very High
Parkinson's Disease 252 99.08 Very High Very High Very High
Aging 24 98.64 Very High Very High Very High
Disease 45 96.52 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 38 96.52 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 178 82.96 Quite High
Stress 16 82.28 Quite High
INFLAMMATION 52 75.44 Quite High
Brain Disease 2 74.00 Quite High
Apoptosis 11 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DA is synthesized from tyrosine by the rate-limiting enzyme tyrosine hydroxylase (TH), to produce L-DOPA which is quickly decarboxylated by L-aromatic acid decarboxylase (L-AADC) to DA [1,3].
Localization (limiting) of TH associated with dopamine
1) Confidence 0.57 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.87
DA is synthesized from tyrosine by the rate-limiting enzyme tyrosine hydroxylase (TH), to produce L-DOPA which is quickly decarboxylated by L-aromatic acid decarboxylase (L-AADC) to DA [1,3].
Localization (limiting) of tyrosine hydroxylase associated with dopamine
2) Confidence 0.57 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.87
Evaluation of pTH, TH, and pDARPP-32 were analyzed using a one-way ANOVA for each brain region.



Localization (Evaluation) of pTH in brain
3) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
Evaluation of pTH, TH, and pDARPP-32 were analyzed using a one-way ANOVA for each brain region.



Localization (Evaluation) of TH in brain
4) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
Tissue sections were then incubated overnight at room temperature in rabbit anti- ser40 pTH (1?
Localization (ser40) of pTH
5) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
Therefore in DAT-KO mice, acute TH inhibition alone by ?
Localization (acute) of TH
6) Confidence 0.49 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.58
These findings are supported by our in vivo studies (Figs. 3 and 6), suggesting the possibility that (i) TH inhibition may be caused by an up-regulation of PP2A activity that is triggered by a-Syn overexpression, (ii) PP2A activation and TH inhibition may be independently triggered by a-Syn overexpression leading to interactions that affect both enzymes, or (iii) that TH inhibition may be an additive consequence of a-Syn overexpression and its ability to activate PP2A.
Neg (inhibition) Localization (inhibition) of TH
7) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.06 Pain Relevance 0.04
The TH in striatum is localized in the axon termini of nigrostriatal dopaminergic neurons (60), where it co-localizes extensively with a-Syn (61).
Localization (localized) of TH in dopaminergic neurons
8) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.24 Pain Relevance 0.04
Here, ageing mice fed with a control diet exhibited a dramatic increase of 3-NT colocalization with TH+ neurons by 3 d after MPTP, corresponding to the active DAergic degeneration phase [27,28,32,33,36], while by 7 d a certain decrease in 3-NT accumulation within TH+ neurons was observed, possibly indicating the end of the degeneration phase.
Localization (colocalization) of TH in neurons associated with parkinson's disease and aging
9) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.95 Pain Relevance 0.27
MPP+ was also more potent than MPTP in releasing endogenous DA from striatal synaptosomes (EC50 = 3 vs. 30 microM), but did not release the cytoplasmic markers tyrosine hydroxylase and lactate dehydrogenase (LDH).
Neg (not) Localization (release) of tyrosine hydroxylase associated with parkinson's disease and dopamine
10) Confidence 0.22 Published 1986 Journal Life Sci. Section Abstract Doc Link 3490612 Disease Relevance 0.60 Pain Relevance 1.03
Double staining showed co-localization of TH in 71±8% of MAP2+ neurons (Fig. 6B).
Localization (localization) of TH in neurons
11) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.23
Tyrosine hydroxylase expression is unaltered in VTA and substantia nigra whereas tyrosine hydroxylase and ?
Localization (whereas) of tyrosine hydroxylase in substantia nigra associated with substantia nigra and midbrain
12) Confidence 0.06 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.94 Pain Relevance 0.52
2A- receptors and adrenergic transporters, catecholamine synthesizing enzymes (tyrosine hydroxylase, DOPA decarboxylase and dopamine-?
Localization (transporters) of tyrosine hydroxylase associated with dopamine and catecholamine
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.12 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox