INT3723

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Context Info
Confidence 0.46
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.83
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
Anatomy Link Frequency
B12 1
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
cocaine 11 99.46 Very High Very High Very High
Inflammation 82 96.60 Very High Very High Very High
rheumatoid arthritis 34 93.20 High High
agonist 5 84.88 Quite High
cytokine 11 79.68 Quite High
chemokine 59 78.80 Quite High
metalloproteinase 5 77.52 Quite High
antagonist 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Atherosclerosis 59 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 58 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 62 99.52 Very High Very High Very High
Cardiovascular Disease 36 98.96 Very High Very High Very High
Hyperhomocysteinemia 1 98.90 Very High Very High Very High
Toxicity 19 98.24 Very High Very High Very High
INFLAMMATION 91 96.60 Very High Very High Very High
Stress 16 94.96 High High
Hypertension 45 94.32 High High
Rheumatoid Arthritis 34 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, it has been suggested that PON1 is significantly associated with atherosclerotic risk.
PON1 Binding (associated) of associated with atherosclerosis
1) Confidence 0.46 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.50 Pain Relevance 0.03
The interaction of 21 morphinan and 25 morphine derivatives with human serum esterase was examined.
serum esterase Binding (interaction) of associated with morphine
2) Confidence 0.42 Published 1981 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7224721 Disease Relevance 0 Pain Relevance 0.18
N-alkylbenzomorphans follow the pattern established in our earlier papers for the interaction of opiates with human serum esterase: they have affinity for both the substrate-binding site of the enzyme and an allosteric site at which agonistic drugs accelerate enzyme action.
serum esterase Binding (interaction) of associated with opiate
3) Confidence 0.42 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7406608 Disease Relevance 0 Pain Relevance 0.25
Study of the interaction of 14-hydroxylated morphines and morphinans with human serum esterase revealed behavior similar to that of other morphine derivates as shown by similar acceleratory efficacies and affinity constants.
serum esterase Binding (interaction) of associated with morphine
4) Confidence 0.41 Published 1977 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 849070 Disease Relevance 0 Pain Relevance 0.35
The potential association between PON genotype and symptoms of chronic pesticide toxicity was examined among 100 farm workers.
PON Binding (association) of associated with toxicity
5) Confidence 0.33 Published 2003 Journal J. Occup. Environ. Med. Section Abstract Doc Link 12625227 Disease Relevance 0.83 Pain Relevance 0.19
The high K(i) value obtained for cocaethylene relative to cocaine is consistent with weaker binding to the esterase and a longer elimination half-life reported for the metabolite.
esterase Binding (binding) of associated with cocaine
6) Confidence 0.19 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9311626 Disease Relevance 0 Pain Relevance 0.49
Indeed, several inflammatory and atherogenic mediators, including homocysteine, lipoprotein (a), C-reactive protein (CRP), hyperhomocysteinemia, and folate, and vitamin B12 deficiency and decreased paraoxonase-1 activity are strongly associated with atherosclerosis and CVD [36,42,43].
paraoxonase-1 Binding (associated) of in B12 associated with inflammation, cardiovascular disease, increased venous pressure under development and hyperhomocysteinemia
7) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 2.33 Pain Relevance 0.64
It is closely associated with the antioxidant enzyme paraoxonase.
paraoxonase Binding (associated) of
8) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.93 Pain Relevance 0
Measurements were made using fluorescent molecular probes, one of which reacts with esterase in live cells and one of which crosses through compromised cell membranes.
esterase Binding (reacts) of
9) Confidence 0.01 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2921296 Disease Relevance 0.08 Pain Relevance 0

General Comments

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