INT37363

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 13.23
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
osteoclast 4
brain 1
articular cartilage 1
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 100.00 Very High Very High Very High
opiate 1 99.42 Very High Very High Very High
Enkephalin 5 99.28 Very High Very High Very High
Osteoarthritis 51 98.92 Very High Very High Very High
substance P 5 98.80 Very High Very High Very High
Endogenous opioid 2 97.96 Very High Very High Very High
Neuropeptide 5 97.64 Very High Very High Very High
antagonist 47 97.32 Very High Very High Very High
Pain 23 96.48 Very High Very High Very High
metalloproteinase 19 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 558 99.96 Very High Very High Very High
Bone Disease 1 99.54 Very High Very High Very High
Hypercalcemia 101 99.40 Very High Very High Very High
Prostate Cancer 40 99.32 Very High Very High Very High
Malignant Neoplastic Disease 9 99.32 Very High Very High Very High
Pancreatitis 6 99.28 Very High Very High Very High
Targeted Disruption 7 99.20 Very High Very High Very High
Osteoarthritis 61 98.92 Very High Very High Very High
Metastasis 275 96.92 Very High Very High Very High
Pain 23 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pathophysiology of malignant osteopathy occurs because of the secretion of substances (such as parathyroid hormone-related peptide), by the malignant cell, which stimulate osteoclast function; this in turn feeds further growth, which causes a vicious cycle.
Localization (secretion) of parathyroid hormone-related in osteoclast associated with malignant neoplastic disease and bone disease
1) Confidence 0.68 Published 2002 Journal Clin. Breast Cancer Section Abstract Doc Link 12196279 Disease Relevance 1.32 Pain Relevance 0.09
PTHrP protein secretion was measured in conditioned medium using a two-site immunoradiometric assay (IRMA) per manufacturer's instructions.
Localization (secretion) of PTHrP
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.05
PTHrP secretion data measured by IRMA changed similarly for all cell lines (Figure 2A–C).
Localization (secretion) of PTHrP
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.29 Pain Relevance 0
In this study, we have shown that tumor cells respond to 2D substrates with rigidities comparable to that of bone by increasing expression and secretion of the osteolytic factor PTHrP.
Localization (secretion) of PTHrP associated with cancer
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.61 Pain Relevance 0
Participants indicated they received information about HHM recycling from local newsletters (e.g., a local community's newsletter sent to all residents had information about paint recycling).
Localization (recycling) of HHM
5) Confidence 0.50 Published 2005 Journal Environ Health Section Body Doc Link PMC1190204 Disease Relevance 0.78 Pain Relevance 0
VEGF, IL-11, and IL-8 ELISAs (R&D) were performed on these samples according to manufacturer's instructions, while PTHrP secretion was measured using a two-site immunoradiometric assay (Beckman Coulter).
Localization (secretion) of PTHrP
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.42 Pain Relevance 0
While VEGF and IL-11 secretion by MDA-MB231 cells were not affected by the scaffold type (Fig. 5A) and PTHrP was secreted at undetectable levels (<0.3 pM) from either mineralized or non-mineralized tumor models (data not shown), IL-8 secretion was increased by 38% in mineralized scaffolds HA (Fig 5A).
Localization (secreted) of PTHrP associated with cancer
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.54 Pain Relevance 0
It was shown that PTHrP is released in high concentrations in OA [13] and is more abundant in knees of patients with OA than in normal human knee articular cartilage [14].
Localization (released) of PTHrP in articular cartilage associated with osteoarthritis
8) Confidence 0.26 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.42 Pain Relevance 0.48
Prostate cancer cells in bone have been shown to secrete factors such as, PTHrP and RANKL [57-59].
Localization (secrete) of PTHrP associated with prostate cancer
9) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.22 Pain Relevance 0.10
An NO-dependent vasodilatory effect of TIP39 was demonstrated if the PTH1R is desensitized by either exogenously administered or endogenously released PTHrP [17,18].
Localization (released) of PTHrP
10) Confidence 0.22 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.38 Pain Relevance 0.13
This hypothesis postulates that factors such as PTHrP [26], RANKL [27] and IL-8 [28] are secreted by cancer cells and stimulate osteoclast recruitment and activity.
Localization (secreted) of PTHrP in osteoclast associated with cancer
11) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.58 Pain Relevance 0.09
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Localization (release) of PTHrP in osteoclast associated with cancer and cytokine
12) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.77 Pain Relevance 0.20
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Localization (release) of parathyroid hormone-related protein in osteoclast associated with cancer and cytokine
13) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.77 Pain Relevance 0.20
However, two adrenocorticotrophic hormone (ACTH)-secreting tumors contained ME, BE, and SP-li amounts that were much higher than both the controls and nonsecreting tumors.
Localization (secreting) of adrenocorticotrophic hormone associated with cancer, enkephalin and substance p
14) Confidence 0.10 Published 1993 Journal Biol. Mass Spectrom. Section Abstract Doc Link 8381675 Disease Relevance 0.61 Pain Relevance 0.86
It is concluded that narcotic antagonist inhibition of endogenous opioid action provides further evidence supporting a role for the brain opiates in the normal regulation of neurohypophysial hormone release in man.
Localization (release) of neurohypophysial hormone in brain associated with antagonist, endogenous opioid and opiate
15) Confidence 0.05 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6103008 Disease Relevance 0 Pain Relevance 0.49
[Secretion of somatotropic hormone in patients with pancreatitis].
Localization (Secretion) of somatotropic hormone associated with pancreatitis
16) Confidence 0.01 Published 1986 Journal Ter. Arkh. Section Title Doc Link 3518116 Disease Relevance 0.53 Pain Relevance 0.24

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