INT37544

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Context Info
Confidence 0.19
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.51
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
plasma 1
blood 1
brain 1
smooth muscle cells 1
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 3 99.98 Very High Very High Very High
Catecholamine 8 99.76 Very High Very High Very High
Serotonin 1 99.12 Very High Very High Very High
bradykinin 17 99.04 Very High Very High Very High
antagonist 81 98.48 Very High Very High Very High
ischemia 19 92.84 High High
Inflammation 53 90.32 High High
Pain 18 80.56 Quite High
Central nervous system 12 75.00 Quite High
cINOD 2 45.40 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 58 99.76 Very High Very High Very High
Toxicity 43 99.32 Very High Very High Very High
Metabolic Syndrome 49 99.20 Very High Very High Very High
Insulin Resistance 54 99.04 Very High Very High Very High
Prediabetic State 36 98.88 Very High Very High Very High
Diabetes Mellitus 166 98.56 Very High Very High Very High
Cancer 482 98.44 Very High Very High Very High
Sepsis 45 97.88 Very High Very High Very High
Lung Cancer 17 96.08 Very High Very High Very High
Coronary Artery Disease 27 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiopoietins and Tie2 receptor complex were shown to play a critical role in tumor angiogenesis; however their roles in brain BMECs remain elusive.
Tie2 receptor Binding (complex) of in brain associated with cancer
1) Confidence 0.19 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.82 Pain Relevance 0
ACE: Angiotensin converting enzyme; Ang II: plasma concentration of angiotensin II; EDTA: ethylenediaminetetraacetate; NIRS: near infrared spectroscopy; PRA: plasma renin activity; RAS: Renin-Angiotensin System; RIA: radioimmune assay; SOFA: Sequential Organ Failure Assessment score; SpO2: percent oxygen saturation of arterial hemoglobin: as measured with pulse oximetry; StO2: percent oxygen saturation of microvascular (tissue) hemoglobin: as measured with NIRS.


Ang II Binding (score) of in plasma
2) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.77 Pain Relevance 0.09
A third group of functions is the synaptic, neurotransmitter interactions of Ang II with catecholamines, serotonin, prostaglandins, and other peptides, not all of which could be reviewed here due to space limitations.
Ang II Binding (interactions) of associated with neurotransmitter, catecholamine and serotonin
3) Confidence 0.10 Published 1987 Journal Annu. Rev. Physiol. Section Abstract Doc Link 3551809 Disease Relevance 0.34 Pain Relevance 0.27
ACE-I alter this balance by decreasing the formation of Ang II and the degradation of bradykinin (Figure 1): the bradykinin is potentiated and NO is released to a greater extent, resulting in decreased migration and proliferation of vascular smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and improved endothelial function.


Ang II Binding (formation) of in smooth muscle cells associated with stress, inflammation and bradykinin
4) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.81 Pain Relevance 0.23
Both bind to the Tie-2 receptor.
Tie-2 receptor Binding (bind) of
5) Confidence 0.06 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.23 Pain Relevance 0
Angiotensin receptor blockers (ARBs) antagonize AT1 receptors and prevent Ang II from binding.
Ang II Binding (binding) of
6) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.25 Pain Relevance 0
Angiotensin II (AngII), the biologically active peptide of the renin-angiotensin system (RAS), is also recognized as a potent mitogen that participates in various pathological situations involving tissue remodeling.
AngII Binding (recognized) of
7) Confidence 0.05 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.99 Pain Relevance 0.05
Angiotensin II (AngII), the biologically active peptide of the renin-angiotensin system (RAS), is a major blood pressure and cardiovascular homeostasis regulator and is also recognized as a potent mitogen.
AngII Binding (recognized) of in blood
8) Confidence 0.05 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.59 Pain Relevance 0.05
Angiotensin II (Ang II) is associated with hypertension, MS, IR, PD, and T2DM both systemically and at the local tissue level.
Ang II Binding (associated) of associated with diabetes mellitus, prediabetic state, hypertension, metabolic syndrome and insulin resistance
9) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.71 Pain Relevance 0

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