INT3793

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Context Info
Confidence 0.61
First Reported 1977
Last Reported 2010
Negated 10
Speculated 2
Reported most in Abstract
Documents 59
Total Number 63
Disease Relevance 20.91
Pain Relevance 15.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CEBPZ) DNA binding (CEBPZ)
Anatomy Link Frequency
blood 13
trachea 2
neuronal 2
brain 1
epithelium 1
CEBPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 93 100.00 Very High Very High Very High
lidocaine 21 100.00 Very High Very High Very High
isoflurane 21 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
narcan 8 100.00 Very High Very High Very High
Migraine 31 99.92 Very High Very High Very High
depression 50 99.84 Very High Very High Very High
cva 464 99.80 Very High Very High Very High
addiction 146 99.80 Very High Very High Very High
c fibre 6 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hematoma 70 100.00 Very High Very High Very High
Body Weight 5 100.00 Very High Very High Very High
Hypercapnia 228 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 48 99.98 Very High Very High Very High
Congenital Anomalies 44 99.96 Very High Very High Very High
Headache 39 99.92 Very High Very High Very High
Depression 56 99.84 Very High Very High Very High
Cv General 3 Under Development 241 99.80 Very High Very High Very High
Ganglion Cysts 2 99.76 Very High Very High Very High
Pressure Volume 2 Under Development 13 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysregulation of CBF may allow relative ischemia to develop in the setting of increased metabolic demand related to neuronal hyperexcitability, may trigger cortical spreading depression, and may predispose individuals with migraine to ischemic lesions and stroke.
Regulation (Dysregulation) of CBF in neuronal associated with depression, stroke, migraine, ischemia and hyperexcitability
1) Confidence 0.61 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18226467 Disease Relevance 1.47 Pain Relevance 1.08
Endogenous opiates are involved in regulation of human CBF, and possibly in hypoperfusion in epileptic foci.
Regulation (regulation) of CBF associated with epilepsy and opiate
2) Confidence 0.61 Published 1993 Journal Epilepsy Res. Section Abstract Doc Link 8243439 Disease Relevance 0.26 Pain Relevance 0.27
Several studies have been performed so far to better understand the influence of baseline CBF and of drug effects on functional activation induced NIRS and BOLD signal changes in humans.
Regulation (influence) of CBF
3) Confidence 0.44 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.09 Pain Relevance 0.04
Altered cerebral blood flow (CBF) has been demonstrated in regions supplied by variant circle of Willis vessels.
Regulation (Altered) of CBF in vessels
4) Confidence 0.39 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18226467 Disease Relevance 1.21 Pain Relevance 0.90
When changes in BOLD signal, CBF, and CBV are measured in the same session in non-human subjects, CBV is measured last because injection of the MRI contrast agent affects the other imaging signals.
Regulation (changes) of CBF associated with imagery
5) Confidence 0.37 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2936934 Disease Relevance 0.07 Pain Relevance 0.17
However, our control subjects did not show any change in the degree of AP-induced changes in the coronary cross-sectional area or CBF; therefore, no effect resulting in cardiac preconditioning was observed in this protocol.
Regulation (change) of CBF
6) Confidence 0.35 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.07 Pain Relevance 0
Empirically, the influence of CMR02 on BOLD signal can be deduced by comparing the responses of CBF and BOLD signal using stimuli that affect CBF and CMR02 i.e. hypercapnia modulates CBF without changing oxygen-utilization.
Regulation (affect) of CBF associated with addiction and hypercapnia
7) Confidence 0.34 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.18 Pain Relevance 0.10
Empirically, the influence of CMR02 on BOLD signal can be deduced by comparing the responses of CBF and BOLD signal using stimuli that affect CBF and CMR02 i.e. hypercapnia modulates CBF without changing oxygen-utilization.
Regulation (responses) of CBF associated with addiction and hypercapnia
8) Confidence 0.34 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.18 Pain Relevance 0.10
Empirically, the influence of CMR02 on BOLD signal can be deduced by comparing the responses of CBF and BOLD signal using stimuli that affect CBF and CMR02 i.e. hypercapnia modulates CBF without changing oxygen-utilization.
Regulation (modulates) of CBF associated with addiction and hypercapnia
9) Confidence 0.34 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.19 Pain Relevance 0.10
If the latter is true, then, in resting conditions, there should be no effect on CBF.
Regulation (effect) of CBF
10) Confidence 0.32 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.34 Pain Relevance 0.21
Trivedi et al. [8] showed marked similarities between changes in the velocity in the MCA and changes in the estimated hemispheric CBF measured with Xenon-133 clearance technique (Figure 2).


Regulation (changes) of CBF
11) Confidence 0.29 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.25 Pain Relevance 0
Similarly, CBF was not significantly altered by HFJV.
Neg (not) Regulation (altered) of CBF
12) Confidence 0.27 Published 1990 Journal Chest Section Abstract Doc Link 2404702 Disease Relevance 0.13 Pain Relevance 0.10
Therefore we studied the response of CBF, the cerebral arteriovenous oxygen content difference (A-VDcereO2) and CMRO2 as a function of the duration of CPB in humans.
Regulation (response) of CBF
13) Confidence 0.27 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1898686 Disease Relevance 0 Pain Relevance 0
The effect of intravenous lidocaine (5 mg/kg body weight) on CBF was investigated in eight healthy subjects and eight long-term diabetic patients with painful neuropathy.
Regulation (effect) of CBF in body associated with pain, body weight, diabetes mellitus and lidocaine
14) Confidence 0.27 Published 1990 Journal J Clin Pharmacol Section Abstract Doc Link 2341579 Disease Relevance 0.63 Pain Relevance 0.86
We have used such ciliated epithelium in an in vitro preparation to study the effects on CBF of lidocaine hydrochloride administered topically in vivo before brushing or in vitro after brushing.
Regulation (effects) of CBF in epithelium associated with lidocaine
15) Confidence 0.24 Published 1981 Journal Chest Section Abstract Doc Link 7307627 Disease Relevance 0 Pain Relevance 0.18
Gender and ethnic origin did not influence CBF in any age group.
Neg (not) Regulation (influence) of CBF
16) Confidence 0.24 Published 1991 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 2024898 Disease Relevance 0 Pain Relevance 0.27
Our results suggest that in patients with normal systemic hemodynamics, the effects of HFJV and IPPV on CBF are comparable at identical levels of mean airway pressure.
Regulation (effects) of CBF
17) Confidence 0.24 Published 1990 Journal Chest Section Abstract Doc Link 2404702 Disease Relevance 0.06 Pain Relevance 0.06
In order to avoid any decrease of cerebral perfusion pressure, which might influence the CBF, an infusion of phenylephrine was used, if needed.
Spec (might) Regulation (influence) of CBF
18) Confidence 0.24 Published 1980 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 6779497 Disease Relevance 0.07 Pain Relevance 0.16
Cerebrovascular responsiveness to changes in PaCO2 was calculated as specific reactivity (SR), the change in CBF divided by the change in PaCO2, expressed in mL.100 g-1.min-1.mm Hg-1.
Regulation (change) of CBF
19) Confidence 0.24 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1898686 Disease Relevance 0 Pain Relevance 0
The effect of lidocaine on CBF in humans is unknown.
Regulation (effect) of CBF associated with lidocaine
20) Confidence 0.24 Published 1990 Journal J Clin Pharmacol Section Abstract Doc Link 2341579 Disease Relevance 0.57 Pain Relevance 0.82

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