INT3797

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Context Info
Confidence 0.47
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.40
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B cells 7
blood 2
erythrocyte 2
CII 2
eosinophil 2
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
Acupuncture 57 98.84 Very High Very High Very High
Arthritis 55 97.92 Very High Very High Very High
cytokine 126 93.44 High High
Inflammation 132 90.68 High High
endometriosis 168 85.92 High High
Inflammatory response 14 82.48 Quite High
rheumatoid arthritis 21 78.08 Quite High
backache 1 74.00 Quite High
headache 4 73.12 Quite High
Paracetamol 1 58.36 Quite High
Disease Link Frequency Relevance Heat
Atherosclerosis 134 99.98 Very High Very High Very High
Immunization 56 99.76 Very High Very High Very High
Cv Unclassified Under Development 1 99.48 Very High Very High Very High
Infection 162 98.76 Very High Very High Very High
Systemic Lupus Erythematosus 66 98.00 Very High Very High Very High
Arthritis 60 97.92 Very High Very High Very High
Epstein-barr Virus 24 96.22 Very High Very High Very High
Autoimmune Disease 19 96.16 Very High Very High Very High
Viral Meningitis 54 94.96 High High
Atherosclerotic Plaque 56 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant association between ST ICT and MT IBT positivity rates and increasing IFA IgM titers (ST ICT and MT IBT Pearson's ?
Positive_regulation (increasing) of Gene_expression (titers) of IgM
1) Confidence 0.47 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0
Other manifestations included neurologic abnormalties, myocardial conduction abnormalities, serum cryoprecipitates, elevated serum IgM levels, and elevated erythrocyte sedimentation rates.
Positive_regulation (elevated) of Gene_expression (levels) of IgM in erythrocyte associated with cv unclassified under development
2) Confidence 0.46 Published 1977 Journal Ann. Intern. Med. Section Abstract Doc Link 869348 Disease Relevance 1.38 Pain Relevance 0.35
contributed to B-cell activation and increased immunoglobulin production (IgM and IgG) of blood B cells [49].
Positive_regulation (increased) of Gene_expression (production) of IgM in B-cell
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of Gene_expression (antibody) of IgM in CII associated with immunization and acupuncture
4) Confidence 0.27 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.96 Pain Relevance 0.91
Conversely the decrease in NF-kappa B/Rel binding at the later time period during the AFC response (Days 2-4) coincides with the inhibitory effects TGF-beta 1 exerted on IgM production by B cells.
Positive_regulation (exerted) of Gene_expression (production) of IgM in B cells
5) Confidence 0.27 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10
TI-2 antigens elicit robust IgM and IgG3 antibody production in a TI fashion, although the presence of noncognate T cell help promotes production of other IgG isotypes (Mongini et al., 1984).
Positive_regulation (elicit) of Gene_expression (production) of IgM in T cell
6) Confidence 0.23 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.08 Pain Relevance 0
There was elevated IgM production in response to the photooxidized grafts.
Positive_regulation (elevated) of Gene_expression (production) of IgM
7) Confidence 0.19 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.08
Our previous study showed a remarkable increase in the levels of autoantibodies including anti-double strand DNA (dsDNA) IgG and IgM antibodies, and anti-nuclear antibody (ANA) in the peripheral blood [17].
Positive_regulation (increase) of Gene_expression (antibodies) of IgM in blood
8) Confidence 0.17 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.10 Pain Relevance 0
ELISA testing showed, after four weeks, production of human collagen-specific IgG antibodies was not induced in the sham-operated negative control mice, however, these mice demonstrated elevated levels of IgM antibodies.
Positive_regulation (elevated) of Gene_expression (antibodies) of IgM
9) Confidence 0.14 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.06 Pain Relevance 0.07
EBV encodes a viral IL-10 homolog, BCRF1 (or vIL-10), that has been shown to increase human B cell proliferation following surface immunoglobulin crosslinkinking and induce B cells to secrete increased levels of IgM, IgG, and IgA in a similar manner to cellular IL-10 [17].
Positive_regulation (increased) of Gene_expression (levels) of IgM in B cells associated with epstein-barr virus
10) Confidence 0.13 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.63 Pain Relevance 0
Herbert et al., showed the possible roles played by IL-5 in innate as well as adaptive immunity against human parasite larvae in mice, by inducing eosinophil production during innate immunity and IgM (Immunoglobulin M) production in the adaptive immune response.
Positive_regulation (inducing) of Gene_expression (production) of IgM in eosinophil
11) Confidence 0.13 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1538622 Disease Relevance 0.55 Pain Relevance 0
Detection of IgM is not always evidence of current infection with certain arboviruses, especially flaviviruses, which can induce persistent IgM production [23,8].
Positive_regulation (induce) of Gene_expression (production) of IgM associated with infection
12) Confidence 0.13 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 1.29 Pain Relevance 0
atherosclerosis induces the production of anti-oxLDL IgM antibodies, which
Positive_regulation (induces) of Gene_expression (production) of IgM associated with atherosclerosis
13) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.59 Pain Relevance 0
atherosclerosis induces the production of anti-oxLDL IgM antibodies, which
Positive_regulation (-) of Gene_expression (production) of IgM associated with atherosclerosis
14) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.59 Pain Relevance 0
While B2 cells can give rise to classical plasma cells producing many distinct immunoglobulin (Ig) isotypes (IgG, IgA), other B cell types including B1 cells, which are present in the peritoneal cavity, and BZM cells, which are located in the marginal zone of the spleen, produce only high levels of IgM to T-independent antigens.
Positive_regulation (levels) of in plasma cells Neg (independent) Gene_expression (produce) of IgM in B cell
15) Confidence 0.03 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.88 Pain Relevance 0.41
Levels of antigen-specific IgM against all antigens were significantly elevated compared to controls 2 weeks after the final vaccine administrations (Table 1).
Positive_regulation (elevated) of Gene_expression (Levels) of IgM
16) Confidence 0.03 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.31 Pain Relevance 0

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