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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.57
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Ripk2) kinase activity (Ripk2) cytoplasm (Ripk2)
Anatomy Link Frequency
brain 1
Ripk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 13 100.00 Very High Very High Very High
analgesia 2 99.38 Very High Very High Very High
agonist 6 98.88 Very High Very High Very High
Endogenous opioid 1 95.96 Very High Very High Very High
cytokine 7 90.24 High High
IPN 3 89.80 High High
antagonist 4 87.12 High High
narcan 2 85.40 High High
MU agonist 2 75.00 Quite High
antinociception 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 5 99.72 Very High Very High Very High
Hyperalgesia 1 92.00 High High
INFLAMMATION 29 70.56 Quite High
Shock 1 58.64 Quite High
Fibrosis 11 56.04 Quite High
Hyperinsulinism 2 49.08 Quite Low
Sprains And Strains 3 46.88 Quite Low
Diabetes Mellitus 1 34.84 Quite Low
Pancreatitis 1 33.60 Quite Low
Targeted Disruption 11 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.
Localization (release) of CCK associated with endogenous opioid, agonist and analgesia
1) Confidence 0.78 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.84
The present reports shows that in different species, regional variations in brain CCK receptor binding occur not only in the case of classical 'brain' receptors, but also for the more discretely localised 'peripheral' type CCK receptors.
Localization (localised) of CCK in brain associated with cholecystokinin
2) Confidence 0.73 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.70
Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(-/-) mice: therapy for exocrine pancreatic disorders?
Localization (secretion) of CCK associated with insulin resistance
3) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17510194 Disease Relevance 0.25 Pain Relevance 0.05
TNF pathway group (19 transcripts): TNF, TNFSF10, TNFSF14, TNFRSF1A, TNFRSF1B, TNFRSF10B, CD27, CD40, LTBR, TNFAIP3, TRAF2, TRAF3, TRADD, TBK1, FADD, CFLAR, RIPK1, RIPK2, and MAP3K1, B.
Localization (group) of RIPK2
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.24 Pain Relevance 0.15

General Comments

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