INT38563

Context Info Confidence 0.56 First Reported 1984 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 18 Total Number 19 Disease Relevance 2.51 Pain Relevance 6.23

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt) cytoplasm (Oxt)

Anatomy Link Frequency neurons 6 nucleus 4 heart 4 PVN 2 Plasma 2 Oxt (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 8 100.00 Opioid 22 99.96 Dynorphin 20 99.80 Morphine 14 99.78 narcan 19 99.46 Enkephalin 10 99.24 Locus ceruleus 6 97.96 Endogenous opioid 3 96.70 Neuropeptide 35 96.24 anesthesia 2 96.24

Disease Link Frequency Relevance Heat Depression 8 100.00 Reprotox - General 1 4 99.56 Stress 33 99.12 Diabetes Mellitus 8 98.68 Infection 4 98.60 Urological Neuroanatomy 27 93.36 Aids-related Complex 9 88.40 Volume Depletion And Dehydration 3 78.08 Hypertension 2 76.84 Natriuresis 2 61.48

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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ISH first showed that chronic morphine treatment inhibited the oxytocin synthesis in SON but not in PVN.

Negative_regulation (inhibited) of Gene_expression (synthesis) of oxytocin in SON associated with morphine

1) Confidence 0.56 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.09 Pain Relevance 0.87

Sexual impotence is associated with a reduced production of oxytocin and with an increased production of opioid peptides in the paraventricular nucleus of male rats.

Negative_regulation (reduced) of Gene_expression (production) of oxytocin in nucleus associated with enkephalin, opioid and reprotox - general 1

2) Confidence 0.51 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9350833 Disease Relevance 0.10 Pain Relevance 0.53

Chronic morphine treatment inhibits oxytocin synthesis in rats.

Negative_regulation (inhibits) of Gene_expression (synthesis) of oxytocin associated with narcan and morphine

3) Confidence 0.49 Published 2000 Journal Neuroreport Section Title Doc Link 11043533 Disease Relevance 0.08 Pain Relevance 0.86

Subcutaneous injection of oxytocin (OXT-(1-9)) and of its behaviorally active fragments desglycinamide9-oxytocin (OXT-(1-8)) and [pGlu4,Cyt6]-oxytocin-(4-8) (OXT-(4-8)) decreased the amount of heroin self-injected.

Negative_regulation (decreased) of Gene_expression (injection) of oxytocin

4) Confidence 0.43 Published 1985 Journal Life Sci. Section Abstract Doc Link 4058258 Disease Relevance 0 Pain Relevance 0.24

Keeping oxytocin neurons under control during stress in pregnancy.

Negative_regulation (Keeping) of Gene_expression (neurons) of oxytocin in neurons associated with stress

5) Confidence 0.43 Published 2008 Journal Prog. Brain Res. Section Title Doc Link 18655896 Disease Relevance 0.24 Pain Relevance 0.16

Focussing on an immune challenge model (since infection is a major cause of preterm labour in women), we have found that the responsiveness of oxytocin neurons to IL-1beta is markedly suppressed in late pregnancy.

Negative_regulation (responsiveness) of Gene_expression (neurons) of oxytocin in neurons associated with infection

6) Confidence 0.43 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.26 Pain Relevance 0.22

Naloxone reveals oxytocin secretion unrestrained by endogenous opioids, therefore it appears that there is an opioid-independent reduction in the excitatory coupling of the AV3V input to oxytocin neurones which may explain the reduced osmoresponsiveness of oxytocin neurones at the end of pregnancy.

Negative_regulation (osmoresponsiveness) of Gene_expression (neurones) of oxytocin associated with endogenous opioid, narcan and opioid

7) Confidence 0.42 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7920592 Disease Relevance 0 Pain Relevance 0.44

Here we show that in sexually impotent rats there is a reduced expression of oxytocin mRNA and an increased expression of proenkephalin and pro-dynorphin mRNA in the paraventricular nucleus of hypothalamus (PVN), a brain structure of key importance for sexual behavior.

Negative_regulation (reduced) of Gene_expression (expression) of oxytocin in PVN associated with dynorphin

8) Confidence 0.37 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9350833 Disease Relevance 0.07 Pain Relevance 0.42

Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination.

Negative_regulation (diminish) of Gene_expression (synthesizing) of oxytocin in neurons associated with opioid

9) Confidence 0.37 Published 2010 Journal Peptides Section Abstract Doc Link 20399242 Disease Relevance 0 Pain Relevance 0.10

Plasma oxytocin levels 40 min after delivery of the first fetus were 45.25 +/- 3.6 pmol/l (mean +/- S.D.) in unoperated controls and significantly (P less than 0.01) depressed (23.89 +/- 3.9) in rats that delivered during infusion of relaxin.

Negative_regulation (depressed) of Gene_expression (levels) of oxytocin in Plasma

10) Confidence 0.37 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3783086 Disease Relevance 0 Pain Relevance 0.27

Quite interestingly, some authors observed a decrease in the gene expression of oxytocin and oxytocin receptors in the heart of young diabetic mice [157].

Negative_regulation (decrease) of Gene_expression (expression) of oxytocin in heart associated with diabetes mellitus

11) Confidence 0.36 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.39 Pain Relevance 0.05

Coronal hypothalamic sections were used for evaluation of Fos, AVP and OT expression by immunohistochemistry.

Negative_regulation (evaluation) of Gene_expression (expression) of OT

12) Confidence 0.32 Published 2007 Journal Stress Section Abstract Doc Link 17853060 Disease Relevance 0.32 Pain Relevance 0.10

Selective, bilateral destruction of the PVN resulted in a parallel depression in levels of ir-VP, ir-OT, ir-dynorphin (DYN), ir-DYN and ir-alpha-neo-endorphin (alpha-NE) in the neurointermediate lobe of the pituitary, whereas in its anterior counter-part no decrease in the content of any of these peptides was seen.

Negative_regulation (depression) of Gene_expression (levels) of OT in pituitary associated with dynorphin and depression

13) Confidence 0.27 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6144057 Disease Relevance 0.10 Pain Relevance 0.58

Quite interestingly, some authors observed a decrease in the gene expression of oxytocin and oxytocin receptors in the heart of young diabetic mice [157].

Negative_regulation (decrease) of Gene_expression (expression) of oxytocin in heart associated with diabetes mellitus

14) Confidence 0.26 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.39 Pain Relevance 0.05

Lesions of the hypothalamic paraventricular nucleus depleted levels of immunoreactive-vasopressin and -oxytocin throughout the cord whereas levels of the opioid peptides therein were unaffected.

Negative_regulation (depleted) of Gene_expression (levels) of oxytocin in nucleus associated with opioid

15) Confidence 0.19 Published 1984 Journal Neuroscience Section Abstract Doc Link 6149493 Disease Relevance 0.08 Pain Relevance 0.77

However, OT did not reproduce the reduction of interspike interval, suggesting the involvement of an additional mechanism.

Negative_regulation (reduction) of Neg (not) Gene_expression (reproduce) of OT

16) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780383 Disease Relevance 0 Pain Relevance 0.07

Alternatively, differences in OT production might be lost as a result of the changing social environment, from a nest with contact with parents to housing with a single sibling.

Negative_regulation (lost) of Gene_expression (production) of OT

17) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0.05 Pain Relevance 0.09

It is possible that alterations in OT-IR were not observed in adult prairie voles because some aspect of physiological and neural maturation from weanling to adult reduces any differences in OT production.

Negative_regulation (reduces) of Gene_expression (production) of OT in neural

18) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0 Pain Relevance 0.07

Previous studies have demonstrated that neonatal manipulation of OT affects the central production of OT [2] and the number and distribution of ER?

Negative_regulation (distribution) of Gene_expression (production) of OT

19) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0.34 Pain Relevance 0.34

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