INT38670

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 68
Total Number 69
Disease Relevance 23.25
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
heart 16
B cell 14
plasma 8
liver 4
muscle tissue 4
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 329 100.00 Very High Very High Very High
Inflammation 172 100.00 Very High Very High Very High
Nav1.7 52 100.00 Very High Very High Very High
rheumatoid arthritis 76 98.56 Very High Very High Very High
cytokine 96 98.52 Very High Very High Very High
imagery 13 97.88 Very High Very High Very High
Arthritis 98 97.20 Very High Very High Very High
Chronic pancreatitis 3 93.48 High High
Angina 10 93.04 High High
antagonist 47 92.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 183 100.00 Very High Very High Very High
Cancer 165 100.00 Very High Very High Very High
Adenocarcinoma 46 100.00 Very High Very High Very High
Metastasis 32 100.00 Very High Very High Very High
Colon Cancer 10 99.98 Very High Very High Very High
Atherosclerosis 46 99.88 Very High Very High Very High
Pancreatic Cancer 11 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 196 99.72 Very High Very High Very High
Disorder Of Lipid Metabolism 6 99.32 Very High Very High Very High
Chronic Lymphoid Leukemia 102 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that CK 20 is overexpressed in pancreatic cancer and that it can serve as an excellent marker for metastatic pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CK 20 associated with pancreatic cancer
1) Confidence 0.69 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.30 Pain Relevance 0.09
In contrast, colon cancers underexpressed CK 20 mRNA by comparison with the respective controls.
Positive_regulation (underexpressed) of Gene_expression (underexpressed) of CK 20 mRNA in colon associated with colon cancer
2) Confidence 0.50 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.28 Pain Relevance 0.08
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (with) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
3) Confidence 0.49 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.47 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (as) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
4) Confidence 0.49 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (studied) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
5) Confidence 0.49 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (functional) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
6) Confidence 0.49 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
Rituximab targets the CD20 molecule, which is selectively expressed on B cells and depletes these cells [26].
Positive_regulation (targets) of Gene_expression (expressed) of CD20 in B cells
7) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.04 Pain Relevance 0.39
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (as) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
8) Confidence 0.43 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (with) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
9) Confidence 0.43 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.47 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (functional) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
10) Confidence 0.43 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.45 Pain Relevance 0.09
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (studied) of Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
11) Confidence 0.43 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.45 Pain Relevance 0.09
This is shown here for a skin metastasis (on the head) of a poorly differentiated adenocarcinoma: the tumor cells are negative for K7 (c) but positive for K20 (d, left portion of the figure), even including a tumor cell cluster that has invaded a lymphatic capillary (d, right upper corner).
Positive_regulation (shown) of in upper Neg (negative) Gene_expression (positive) of K20 in skin associated with adenocarcinoma, cancer and metastasis
12) Confidence 0.29 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.61 Pain Relevance 0
CD20+CD45RO+ expression was increased in one-third of patients but did not correlate with permeability abnormalities.
Positive_regulation (increased) of Gene_expression (expression) of CD20
13) Confidence 0.15 Published 1999 Journal J. Rheumatol. Section Body Doc Link 9918253 Disease Relevance 0 Pain Relevance 0
Increased CD20+CD45RO+ expression suggests increased antigen exposure, which may be related to previous or current intestinal permeability abnormalities.


Positive_regulation (Increased) of Gene_expression (expression) of CD20
14) Confidence 0.15 Published 1999 Journal J. Rheumatol. Section Body Doc Link 9918253 Disease Relevance 0 Pain Relevance 0
SLE patients showed increased frequencies of CD27++/CD20?
Positive_regulation (frequencies) of Gene_expression (/) of CD20 associated with systemic lupus erythematosus
15) Confidence 0.15 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.48 Pain Relevance 0
On admission (day 0), both SLE patients had elevated frequencies and absolute numbers of CD27++/CD20?
Positive_regulation (elevated) of Gene_expression (frequencies) of CD20 associated with systemic lupus erythematosus
16) Confidence 0.15 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.93 Pain Relevance 0
Within the group of SLE patients, the presence of serum anti-RNP antibodies (N = 13) was found to be associated with a higher frequency of CD27++/CD20?
Positive_regulation (frequency) of Gene_expression (/) of CD20 associated with systemic lupus erythematosus
17) Confidence 0.15 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.30 Pain Relevance 0
Finally, other authors have demonstrated that it is possible to enhance rituximab efficacy through upregulation of CD20 antigen expression on tumor cells from CLL patients by cytokines such as IL-4, granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumour necrosis factor-?
Spec (possible) Positive_regulation (upregulation) of Gene_expression (expression) of CD20 in macrophage associated with chronic lymphoid leukemia, necrosis, cancer and cytokine
18) Confidence 0.10 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 1.00 Pain Relevance 0.05
MCs were followed for over four weeks in culture, but proliferating CK20-positive cells were detected only during the first two weeks after enrichment.
Positive_regulation (followed) of Gene_expression (proliferating) of CK20
19) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0
A significant increase in the numbers of B cells with CD20+ CD5+ phenotype which is correlated with autoantibody production and with CD21 markers that is a ligand for retroviruses was also found in patients with CFS [61].
Positive_regulation (increase) of Gene_expression (phenotype) of CD20 in B cells associated with chronic fatigue syndrome
20) Confidence 0.07 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 1.66 Pain Relevance 0.49

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